ArticleThe American journal of gastroenterology2011
Translumbar and transsacral motor-evoked potentials: a novel test for spino-anorectal neuropathy in spinal cord injury.
Article in The American journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07192328 (Randomized Cross-Over Dose-Efficacy Study of rTMS in Healthy Young Female Volunteers), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Cross-Over Dose-Efficacy Study of rTMS in Healthy Young Female Volunteers
Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Frequency-Dependent Effects of Transcranial and Translumbosacral Magnetic Stimulation on Anorectal Neurophysiology: A Dose-Response Study in Healthy Women.Neurogastroenterology and motility · 2026Trial
- Randomised clinical trial: linaclotide vs placebo-a study of bi-directional gut and brain axis.Alimentary pharmacology & therapeutics · 2020Trial
- Translumbar and transsacral magnetic neurostimulation for the assessment of neuropathy in fecal incontinence.Diseases of the colon and rectum · 2014Trial
- Intraoperative neurophysiological monitoring reduces postoperative constipation in unilateral biportal endoscopic lumbar spine surgery.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2026Article
- Controversies in fecal incontinence.World journal of gastroenterology · 2025Article
- Faecal incontinence in adults.Nature reviews. Disease primers · 2022Review
- Translumbosacral Anorectal Magnetic Stimulation Test for Fecal Incontinence.Diseases of the colon and rectum · 2022Observational
- Comparative effectiveness of biofeedback and injectable bulking agents for treatment of fecal incontinence: Design and methods.Contemporary clinical trials · 2021Article
- Clinical Evaluation of a Patient With Symptoms of Colonic or Anorectal Motility Disorders.Journal of neurogastroenterology and motility · 2020Review
- Bowel Dysfunction in Spinal Cord Injury.Current gastroenterology reports · 2018Review
- Expert consensus document: Advances in the evaluation of anorectal function.Nature reviews. Gastroenterology & hepatology · 2018Review
- Constipation in Parkinson's Disease: a Nuisance or Nuanced Answer to the Pathophysiological Puzzle?Current gastroenterology reports · 2018Review
- Functional Anorectal Disorders.Gastroenterology · 2016Article
- Fecal Incontinence: Etiology, Diagnosis, and Management.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Review
- Current and emerging treatment options for fecal incontinence.Journal of clinical gastroenterology · 2014Review
- An update on anorectal disorders for gastroenterologists.Gastroenterology · 2014Review
- What's New in the Toolbox for Constipation and Fecal Incontinence?Frontiers in medicine · 2014Review
- Neurogenic bowel dysfunction in patients with spinal cord injury, myelomeningocele, multiple sclerosis and Parkinson's disease.World journal of gastroenterology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
objectivesSpinal cord injury (SCI) causes anorectal problems, whose pathophysiology remains poorly characterized. A comprehensive method of evaluating spino-anorectal function is lacking. The aim of this study was to investigate the neuropathophysiology of bowel dysfunction in SCI by evaluating motor-evoked potentials (MEP) of anus and rectum following transspinal magnetic stimulation and anorectal physiology.
methodsTranslumbar and transsacral magnetic stimulations, anorectal manometry, and pudendal nerve terminal motor latency (PNTML) were performed in 39 subjects with SCI and anorectal problems and in 14 healthy controls, and data were compared. MEPs were recorded with an anorectal probe containing bipolar ring electrodes.
resultsThe MEPs were significantly prolonged (P<0.05) bilaterally, and at lumbar and sacral levels, as well as at rectal and anal sites in SCI subjects compared with controls. A total of 95% of SCI subjects had abnormal MEPs and 53% had abnormal PNTML. All subjects with abnormal PNTML also demonstrated abnormal MEP, but 16/17 subjects with normal PNTML had abnormal MEP. Overall, SCI patients had weaker anal sphincters (P<0.05), higher prevalence of dyssynergia (85%), and altered rectal sensation (82%).
conclusionsTranslumbar and transsacral MEPs revealed significant and hitherto undetected lumbosacral neuropathy in 90% of SCI subjects. Test was safe and provided neuropathophysiological information that could explain bowel dysfunction in SCI subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.