ArticleThe Journal of biological chemistry2011
Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Lipidomics of skin tissues from different hair types of Inner Mongolia cashmere goats.BMC veterinary research · 2026Article
- PLA2G2F/lysoplasmalogen axis links epidermal lipid metabolism to type 2 inflammation and itch in atopic dermatitis.Frontiers in immunology · 2026Article
- Comprehensive analysis of differences in cashmere production performance in Liaoning cashmere goats by using metabolomics and transcriptomics.Frontiers in veterinary science · 2025Article
- Novel variant inFrontiers in genetics · 2025Article
- Analysis of 72,469 UK Biobank exomes links rare variants to male-pattern hair loss.Nature communications · 2023Article
- The Roles of sPLABiomolecules · 2023Review
- Epidermal Fatty Acid‒Binding Protein Mediates Depilatory-Induced Acute Skin Inflammation.The Journal of investigative dermatology · 2022Article
- Group V secreted phospholipase AThe Journal of biological chemistry · 2020Article
- Context-dependent effect of sPLAEBioMedicine · 2019Article
- Group IID, IIE, IIF and III secreted phospholipase ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2019Review
- Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia.Journal of the American Academy of Dermatology · 2018Article
- Phospholipase AInflammation and regeneration · 2018Review
- Secretory phospholipase AScientific reports · 2017Article
- Expression and Function of Group IIE Phospholipase A2 in Mouse Skin.The Journal of biological chemistry · 2016Article
- Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.The Journal of biological chemistry · 2016Article
- The Roles of the Secreted Phospholipase AAdvances in immunology · 2016Review
- Metabolic regulation by secreted phospholipase AInflammation and regeneration · 2016Review
- The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.The Journal of experimental medicine · 2015Article
- A new era of secreted phospholipase A₂.Journal of lipid research · 2015Article
Corrections and comments
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Authors and funding
20 authors at 11 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although perturbed lipid metabolism can often lead to skin abnormality, the role of phospholipase A(2) (PLA(2)) in skin homeostasis is poorly understood. In the present study we found that group X-secreted PLA(2) (sPLA(2)-X) was expressed in the outermost epithelium of hair follicles in synchrony with the anagen phase of hair cycling. Transgenic mice overexpressing sPLA(2)-X (PLA2G10-Tg) displayed alopecia, which was accompanied by hair follicle distortion with reduced expression of genes related to hair development, during a postnatal hair cycle. Additionally, the epidermis and sebaceous glands of PLA2G10-Tg skin were hyperplasic. Proteolytic activation of sPLA(2)-X in PLA2G10-Tg skin was accompanied by preferential hydrolysis of phosphatidylethanolamine species with polyunsaturated fatty acids as well as elevated production of some if not all eicosanoids. Importantly, the skin of Pla2g10-deficient mice had abnormal hair follicles with noticeable reduction in a subset of hair genes, a hypoplasic outer root sheath, a reduced number of melanin granules, and unexpected up-regulation of prostanoid synthesis. Collectively, our study highlights the spatiotemporal expression of sPLA(2)-X in hair follicles, the presence of skin-specific machinery leading to sPLA(2)-X activation, a functional link of sPLA(2)-X with hair follicle homeostasis, and compartmentalization of the prostanoid pathway in hair follicles and epidermis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.