ArticleJournal of cell science2011
An RNA-zipcode-independent mechanism that localizes Dia1 mRNA to the perinuclear ER through interactions between Dia1 nascent peptide and Rho-GTP.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Regulation and outcomes of localized RNA translation.Wiley interdisciplinary reviews. RNA · 2022Review
- Intracellular mRNA transport and localized translation.Nature reviews. Molecular cell biology · 2021Review
- Systematics for types and effects of RNA variations.RNA biology · 2021Article
- mRNA Targeting, Transport and Local Translation in Eukaryotic Cells: From the Classical View to a Diversity of New Concepts.Molecular biology · 2021Article
- The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs.Molecular neurobiology · 2020Article
- The ABD on the nascent polypeptide and PH domain are required for the precise Anillin localization in Drosophila syncytial blastoderm.Scientific reports · 2018Article
- Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds.Chemistry & biology · 2015Article
- Formins: linking cytoskeleton and endomembranes in plant cells.International journal of molecular sciences · 2014Review
- Here, there, everywhere. mRNA localization in budding yeast.RNA biology · 2014Review
- Sounds of silence: synonymous nucleotides as a key to biological regulation and complexity.Nucleic acids research · 2013Review
- Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblasts.PloS one · 2013Article
- Analogue encoding of physicochemical properties of proteins in their cognate messenger RNAs.Nature communications · 2013Article
- mRNA localization: an orchestration of assembly, traffic and synthesis.Traffic (Copenhagen, Denmark) · 2013Review
- Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling.The Journal of biological chemistry · 2012Article
- Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture.Molecular biology of the cell · 2011Article
- How and why does Dia1 mRNA localize?Communicative & integrative biology · 2011Article
- Cotranslational transport of ABP140 mRNA to the distal pole of S. cerevisiae.The EMBO journal · 2011Article
- Mis-localization of Arp2 mRNA impairs persistence of directional cell migration.Experimental cell research · 2011Article
- Control of cell migration through mRNA localization and local translation.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Signal-peptide-mediated ER localization of mRNAs encoding for membrane and secreted proteins, and RNA-zipcode-mediated intracellular targeting of mRNAs encoding for cytosolic proteins are two well-known mechanisms for mRNA localization. Here, we report a previously unidentified mechanism by which mRNA encoding for Dia1, a cytosolic protein without the signal peptide, is localized to the perinuclear ER in an RNA-zipcode-independent manner in fibroblasts. Dia1 mRNA localization is also independent of the actin and microtubule cytoskeleton but requires translation and the association of Dia1 nascent peptide with the ribosome-mRNA complex. Sequence mapping suggests that interactions of the GTPase binding domain of Dia1 peptide with active Rho are important for Dia1 mRNA localization. This mechanism can override the β-actin RNA zipcode and redirect β-actin mRNA to the perinuclear region, providing a new way to manipulate intracellular mRNA localization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.