Evidence map›Paper›PMID 21266347›Full record

ReviewBriefings in functional genomics2010

Next generation sequencing based approaches to epigenomics.

Martin Hirst, Marco A Marra

Abstract readReview
In one paragraph

Review in Briefings in functional genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
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  9. -Omic and Electronic Health Record Big Data Analytics for Precision Medicine.IEEE transactions on bio-medical engineering · 2017
    Review
  10. Article
  11. Article
  12. Space, the final frontier: A critical review of recent experiments performed in microgravity.Plant science : an international journal of experimental plant biology · 2016
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Prostate cancer epigenome.Methods in molecular biology (Clifton, N.J.) · 2015
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Martin HirstGenome Sciences Centre, Vancouver, BC, Canada. mhirst@bcgsc.ca
Marco A Marra

Funding

Integrated Epigenetic Maps of Human Embryonic and Adult CellsU01ES017154 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COSTELLO, JOSEPH F, MARRA, MARCO ANTONIO · 2008 to 2012
$11.6M
CIHR 92093NIEHS NIH HHS 5U01ES017154-02NIEHS NIH HHS U01 ES017154
6 · The paper itself

Abstract

Next generation sequencing has brought epigenomic studies to the forefront of current research. The power of massively parallel sequencing coupled to innovative molecular and computational techniques has allowed researchers to profile the epigenome at resolutions that were unimaginable only a few years ago. With early proof of concept studies published, the field is now moving into the next phase where the importance of method standardization and rigorous quality control are becoming paramount. In this review we will describe methodologies that have been developed to profile the epigenome using next generation sequencing platforms. We will discuss these in terms of library preparation, sequence platforms and analysis techniques.

Indexed as

EpigenomicsHigh-Throughput Nucleotide SequencingAnimalsBase SequenceHumansSequence Analysis, DNA

Identifiers

PMID21266347
PMCPMC3080743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.