ArticleSeminars in nephrology2011
Renin angiotensin signaling in normal pregnancy and preeclampsia.
Article in Seminars in nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- Active plasma renin concentration throughout healthy and complicated pregnancy: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Protein profiling of preeclampsia placental tissues.PloS one · 2014Trial
- Preeclampsia Is a Double-Hit Vascular Disorder: The VEGF-HO-1-CSE Axis.Biomolecules · 2026Review
- Cardiovascular complications of pregnancy.The Journal of clinical investigation · 2026Review
- The multifactorial role of HDAC9 at the maternal-fetal interface in the pathogenesis of preeclampsia.Clinical science (London, England : 1979) · 2025Review
- Gating Mechanism for Biased Agonism at Angiotensin II Type 1 Receptors.Molecules (Basel, Switzerland) · 2025Article
- Importance of the (Pro)renin Receptor in Activating the Renin-Angiotensin System During Normotensive and Preeclamptic Pregnancies.Current hypertension reports · 2024Review
- Relationship between hypertensive disease stages of pregnancy and plateletcrit values: A retrospective cohort study.Heliyon · 2024Article
- Genetic Insights and Neonatal Outcomes in Preeclampsia and Eclampsia: A Detailed Analysis of the RS5707 Genotype.Diagnostics (Basel, Switzerland) · 2024Article
- Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection.Current hypertension reports · 2024Review
- Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.Biochemical pharmacology · 2024Review
- Non-invasive prediction of preeclampsia using the maternal plasma cell-free DNA profile and clinical risk factors.Frontiers in medicine · 2024Article
- Commentary on: Increased stiffness of omental arteries from late pregnant women at advanced maternal age.Bioscience reports · 2023Article
- Investigation of CD56, ADAM17 and FGF21 Expressions in the Placentas of Preeclampsia Cases.Medicina (Kaunas, Lithuania) · 2023Article
- Setting a stage: Inflammation during preeclampsia and postpartum.Frontiers in physiology · 2023Review
- Review
- Glomerular hyperfiltration.Nature reviews. Nephrology · 2022Review
- Pregnancy, Preeclampsia, and COVID-19: Susceptibility and Mechanisms: A Review Study.International journal of fertility & sterility · 2022Review
- Maternal Nanomaterial Inhalation Exposure: Critical Gestational Period in the Uterine Microcirculation is Angiotensin II Dependent.Cardiovascular toxicology · 2022Article
- Molecular and Physiological Aspects of SARS-CoV-2 Infection in Women and Pregnancy.Frontiers in global women's health · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many reports indicate that there is an increase in almost all of the components of the renin-angiotensin system (RAS) during an uncomplicated pregnancy, but renin activity, angiotensin II, and aldosterone decrease in preeclampsia (PE) for reasons that are unclear. PE is a life-threatening disorder of late pregnancy characterized by hypertension, proteinuria, increased soluble fms-like tyrosine kinase-1, as well as renal and placental morphologic abnormalities. Although a leading cause of maternal and perinatal morbidity and mortality, the pathogenic mechanisms of PE remain largely undefined. Immunologic mechanisms and aberrations of the RAS have been long considered contributors to the disorder. Bridging these two concepts, numerous studies report the presence of the angiotensin II type I receptor agonistic autoantibody (AT(1)-AA) found circulating in preeclamptic women. This autoantibody induces many key features of the disorder through AT(1) receptor signaling, and has been implicated in the pathogenesis of PE. Here we review the functions of the RAS during normal pregnancy and PE, and highlight the role of AT(1)-AA in both animal models and in the human disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.