ArticleBiochemical and biophysical research communications2011
Ataxia telangiectasia mutated influences cytochrome c oxidase activity.
Article in Biochemical and biophysical research communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype.Stem cells translational medicine · 2012Trial
- The interplay between DNA damage response and mitochondrial dysfunction in radiotherapy.Frontiers in oncology · 2025Review
- Phenformin and ataxia-telangiectasia mutated inhibitors synergistically co-suppress liver cancer cell growth by damaging mitochondria.FEBS open bio · 2021Article
- Ataxia Telangiectasia Mutated Protein Kinase: A Potential Master Puppeteer of Oxidative Stress-Induced Metabolic Recycling.Oxidative medicine and cellular longevity · 2021Review
- A Dual Role of ATM in Ischemic Preconditioning and Ischemic Injury.Cellular and molecular neurobiology · 2020Article
- Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation.Scientific reports · 2019Article
- Reduction in the Level of Plasma Mitochondrial DNA in Human Diving, Followed by an Increase in the Event of an Accident.Frontiers in physiology · 2018Article
- Trans-Plasma Membrane Electron Transport and Ascorbate Efflux by Skeletal Muscle.Antioxidants (Basel, Switzerland) · 2017Article
- Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks.Frontiers in cellular neuroscience · 2017Article
- Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction.Redox biology · 2015Article
- NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells.Free radical biology & medicine · 2014Article
- Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging.Microbial cell (Graz, Austria) · 2014Review
- The Aspergillus nidulans ATM kinase regulates mitochondrial function, glucose uptake and the carbon starvation response.G3 (Bethesda, Md.) · 2014Article
- Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.DNA repair · 2014Article
- Impaired insulin-stimulated glucose transport in ATM-deficient mouse skeletal muscle.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2013Article
- Review
- Axis of ageing: telomeres, p53 and mitochondria.Nature reviews. Molecular cell biology · 2012Review
- The ATM protein kinase and cellular redox signaling: beyond the DNA damage response.Trends in biochemical sciences · 2012Review
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cells lacking ataxia telangiectasia mutated (ATM) have impaired mitochondrial function. Furthermore, mammalian cells lacking ATM have increased levels of reactive oxygen species (ROS) as well as mitochondrial DNA (mtDNA) deletions in the region encoding for cytochrome c oxidase (COX). We hypothesized that ATM specifically influences COX activity in skeletal muscle. COX activity was ∼40% lower in tibialis anterior from ATM-deficient mice than for wild-type mice (P < 0.01, n = 9/group). However, there were no ATM-related differences in activity of succinate dehydrogenase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, mitochondrial glycerol 3-phosphate dehydrogenase, or complex III. Incubation of wild-type extensor digitorum longus muscles for 1h with the ATM inhibitor KU55933 caused a ∼50% reduction (P<0.05, n = 5/group) in COX activity compared to muscles incubated with vehicle alone. Among the control muscles and muscles treated with the ATM inhibitor, COX activity was correlated (r = 0.61, P<0.05) with activity of glucose 6-phosphate dehydrogenase, a key determinant of antioxidant defense through production of NADPH. Overall, the findings suggest that ATM has a protective role for COX activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.