ArticleRadiation research2011
Murine Prkdc polymorphisms impact DNA-PKcs function.
Article in Radiation research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
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- Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice.Disease models & mechanisms · 2021Article
- BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Transcriptional response in normal mouse tissues after i.v. (211)At administration - response related to absorbed dose, dose rate, and time.EJNMMI research · 2015Article
- Biological Effects of Space Radiation and Development of Effective Countermeasures.Life sciences in space research · 2014Article
- Hindlimb suspension and SPE-like radiation impairs clearance of bacterial infections.PloS one · 2014Article
- Fine mapping of the Bmgr5 quantitative trait locus for allogeneic bone marrow engraftment in mice.Immunogenetics · 2013Article
- Amino acid changes in disease-associated variants differ radically from variants observed in the 1000 genomes project dataset.PLoS computational biology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Polymorphic variants of DNA repair genes can increase the carcinogenic potential of exposure to ionizing radiation. Two single nucleotide polymorphisms (SNPs) in Prkdc, the gene encoding the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), have been identified in BALB/c mice and linked to reduced DNA-PKcs activity and mammary cancer susceptibility. We examined three additional mouse strains to better define the roles of the BALB/c Prkdc SNPs (R2140C and M3844V). One is a congenic strain (C.B6) that has the C57BL/6 Prkdc allele on a BALB/c background, and the other is a congenic strain (B6.C) that has the BALB/c variant Prkdc allele on a C57BL/6 background. We also examined the LEWES mouse strain, which possesses only one of the BALB/c Prkdc SNPs (M3844V). Our results demonstrate that both Prkdc SNPs are responsible for deficient DNA-PKcs protein expression, DNA repair and telomere function, while the LEWES SNP affects only DNA-PKcs expression and repair capacity. These studies provide insight into the separation of function between the two BALB/c SNPs as well as direct evidence that SNPs positioned within Prkdc can significantly influence DNA-PKcs function involving DNA repair capacity, telomere end-capping, and potentially cancer susceptibility.
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