ReviewMacromolecular bioscience2011
Biomimetic approaches to control soluble concentration gradients in biomaterials.
Review in Macromolecular bioscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Peptide concentration gradients and aligned microfiber topography synergize to speed and direct Schwann cell migration.Acta biomaterialia · 2026Article
- Hydrogel-based microenvironment engineering of haematopoietic stem cells.Cellular and molecular life sciences : CMLS · 2023Review
- Advancing models of neural development with biomaterials.Nature reviews. Neuroscience · 2021Review
- Convection-driven microfabricated hydrogels for rapid biosensing.The Analyst · 2020Article
- Genetically-programmed, mesenchymal stromal cell-laden & mechanically strong 3D bioprinted scaffolds for bone repair.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Engineered materials for organoid systems.Nature reviews. Materials · 2019Article
- Review
- Engineering Hydrogel Microenvironments to Recapitulate the Stem Cell Niche.Annual review of biomedical engineering · 2018Review
- Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions.Journal of materials science. Materials in medicine · 2017Article
- DNA orientation-specific adhesion and patterning of living mammalian cells on self-assembled DNA monolayers.Chemical science · 2016Article
- Progress in material design for biomedical applications.Proceedings of the National Academy of Sciences of the United States of America · 2015Review
- Context clues: the importance of stem cell-material interactions.ACS chemical biology · 2014Review
- Biochemical and physical signal gradients in hydrogels to control stem cell behavior.Advanced materials (Deerfield Beach, Fla.) · 2013Article
- Gradients of physical and biochemical cues on polyelectrolyte multilayer films generated via microfluidics.Lab on a chip · 2013Article
- Material strategies for creating artificial cell-instructive niches.Current opinion in biotechnology · 2012Review
- Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation.Current opinion in biotechnology · 2012Review
- Moving from static to dynamic complexity in hydrogel design.Nature communications · 2012Article
- Chemically well-defined self-assembled monolayers for cell culture: toward mimicking the natural ECM.Soft matter · 2011Article
- Engineering biomaterial systems to enhance viral vector gene delivery.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Soluble concentration gradients play a critical role in controlling tissue formation during embryonic development. The importance of soluble signaling in biology has motivated engineers to design systems that allow precise and quantitative manipulation of gradient formation in vitro. Engineering techniques have increasingly moved to the third dimension in order to provide more physiologically relevant models to study the biological role of gradient formation and to guide strategies for controlling new tissue formation for therapeutic applications. This review provides an overview of efforts to design biomimetic strategies for soluble gradient formation, with a focus on microfluidic techniques and biomaterials approaches for moving gradient generation to the third dimension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.