Trial reportNeurocritical care2011
Anti-adrenergic medications and edema development after intracerebral hemorrhage.
Trial report in Neurocritical care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Pooled it
- Pooled it
- The association between perihaematomal oedema and functional outcome after spontaneous intracerebral haemorrhage: A systematic review and meta-analysis.European stroke journal · 2023Pooled it
- Perihematomal Edema and Clinical Outcome After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.Neurocritical care · 2022Pooled it
- The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage.PloS one · 2015Trial
- High dose deferoxamine in intracerebral hemorrhage (HI-DEF) trial: rationale, design, and methods.Neurocritical care · 2013Trial
- Hypothalamus Participates in Peripheral Sympathetic Hyperactivity After Acute Brain Injury by RegulatingMedComm · 2026Article
- Early Cardiac Workload and Long-Term Prognosis After Intracerebral Hemorrhage: Insights from a Large Multicenter Cohort.Reviews in cardiovascular medicine · 2026Article
- A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence.Bioengineering (Basel, Switzerland) · 2024Article
- Autonomic dysfunction and treatment strategies in intracerebral hemorrhage.CNS neuroscience & therapeutics · 2024Review
- Neuro-imaging in intracerebral hemorrhage: updates and knowledge gaps.Frontiers in neuroscience · 2024Review
- Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging - A pilot study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023Article
- The association between blood pressure variability and perihematomal edema after spontaneous intracerebral hemorrhage.Frontiers in neurology · 2023Article
- Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials.Frontiers in stroke · 2023Review
- Efficacy and safety of glibenclamide therapy after intracerebral haemorrhage (GATE-ICH): A multicentre, prospective, randomised, controlled, open-label, blinded-endpoint, phase 2 clinical trial.EClinicalMedicine · 2022Article
- Zebrafish drug screening identifies candidate therapies for neuroprotection after spontaneous intracerebral haemorrhage.Disease models & mechanisms · 2022Article
- Cerebral small vessel disease and perihematomal edema formation in spontaneous intracerebral hemorrhage.Frontiers in neurology · 2022Article
- Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Perihematomal Edema After Intracerebral Hemorrhage: An Update on Pathogenesis, Risk Factors, and Therapeutic Advances.Frontiers in immunology · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUse of antihypertensive medications is common after intracerebral hemorrhage (ICH). Medications that block adrenergic activation (e.g., beta-blockers and the alpha(2)-agonist, clonidine) may reduce the inflammatory response and therefore have secondary benefit after ICH.
methodsThe patients with acute ICH enrolled in the placebo arm of the CHANT trial were included. Univariate and multivariate analyses were undertaken for factors associated with blood pressure medication use, edema at 72 h, and clinical outcome at 90 days.
resultsOf the 303 patients, 87.8% received some antihypertensive treatment during the first 72 h of hospitalization. Edema volume on neuroimaging at 72 h was independently associated with clinical outcome. Use of anti-adrenergic medications was associated with less edema after controlling for hemorrhage volume and blood pressure.
conclusionsAntihypertensive medications that antagonize the sympathetic nervous system may reduce perihematomal edema after ICH.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.