ArticleBreast cancer research and treatment2011
Genome-wide copy number alterations in subtypes of invasive breast cancers in young white and African American women.
Article in Breast cancer research and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Associations of Age With Tumor Genomic Characteristics in Relapsed/Refractory Cancers Interrogated With the NCI-MATCH Trial Targeted Gene Panel Assay.JCO precision oncology · 2026Article
- Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer.Oncogene · 2024Article
- Can COVID-19 worsen racial disparities in breast cancer screening and diagnosis?Journal of clinical imaging science · 2022Article
- Genomic Alterations during theMolecular cancer research : MCR · 2021Article
- Breast and prostate cancers harbor common somatic copy number alterations that consistently differ by race and are associated with survival.BMC medical genomics · 2020Article
- Molecular and Cellular Factors Associated with Racial Disparity in Breast Cancer.International journal of molecular sciences · 2020Review
- Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced ObesityJournal of medicinal chemistry · 2020Article
- Health and Racial Disparity in Breast Cancer.Advances in experimental medicine and biology · 2019Review
- Predictive genomic markers of response to VEGF targeted therapy in metastatic renal cell carcinoma.PloS one · 2019Article
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- Emerging evidence for the role of differential tumor microenvironment in breast cancer racial disparity: a closer look at the surroundings.Carcinogenesis · 2017Review
- Assessing the Racial and Ethnic Disparities in Breast Cancer Mortality in the United States.International journal of environmental research and public health · 2017Review
- Basal-like breast cancer: molecular profiles, clinical features and survival outcomes.BMC medical genomics · 2017Article
- Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?Trends in cancer · 2017Review
- Lower frequency of TLR9 variant associated with protection from breast cancer among African Americans.PloS one · 2017Article
- Differentially expressed miRNAs in triple negative breast cancer between African-American and non-Hispanic white women.Oncotarget · 2016Article
- Tracking Cancer Genetic Evolution using OncoTrack.Scientific reports · 2016Article
- CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance.Cell research · 2016Article
- Review
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Genomic copy number alterations (CNA) are common in breast cancer. Identifying characteristic CNAs associated with specific breast cancer subtypes is a critical step in defining potential mechanisms of disease initiation and progression. We used genome-wide array comparative genomic hybridization to identify distinctive CNAs in breast cancer subtypes from 259 young (diagnosed with breast cancer at <55 years) African American (AA) and Caucasian American (CA) women originally enrolled in a larger population-based study. We compared the average frequency of CNAs across the whole genome for each breast tumor subtype and found that estrogen receptor (ER)-negative tumors had a higher average frequency of genome-wide gain (P < 0.0001) and loss (P = 0.02) compared to ER-positive tumors. Triple-negative (TN) tumors had a higher average frequency of genome-wide gain (P < 0.0001) and loss (P = 0.003) than non-TN tumors. No significant difference in CNA frequency was observed between HER2-positive and -negative tumors. We also identified previously unreported recurrent CNAs (frequency >40%) for TN breast tumors at 10q, 11p, 11q, 16q, 20p, and 20q. In addition, we report CNAs that differ in frequency between TN breast tumors of AA and CA women. This is of particular relevance because TN breast cancer is associated with higher mortality and young AA women have higher rates of TN breast tumors compared to CA women. These data support the possibility that higher overall frequency of genomic alteration events as well as specific focal CNAs in TN breast tumors might contribute in part to the poor breast cancer prognosis for young AA women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.