ArticlePloS one2011
Pavlovian fear conditioning activates a common pattern of neurons in the lateral amygdala of individual brains.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Effects of ketamine on fear memory extinction: a review of preclinical literature.Frontiers in neuroscience · 2025Pooled it
- The proto-cortical amygdala: a perspective on the functional and evolutionary relationship between the basolateral amygdala complex and neocortex in mammals.Brain structure & function · 2026Review
- The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models.Translational psychiatry · 2024Article
- Specific patterns of neural activity in the hippocampus after massed or distributed spatial training.Scientific reports · 2023Article
- Retrieval of olfactory fear memory alters cell proliferation and expression of pCREB and pMAPK in the corticomedial amygdala and piriform cortex.Chemical senses · 2022Article
- Contextual Fear Memory Maintenance Changes Expression of pMAPK, BDNF and IBA-1 in the Pre-limbic Cortex in a Layer-Specific Manner.Frontiers in neural circuits · 2021Article
- Assaying Fear Memory Discrimination and Generalization: Methods and Concepts.Current protocols in neuroscience · 2020Article
- Chemogenetic stimulation of the infralimbic cortex reverses alcohol-induced fear memory overgeneralization.Scientific reports · 2019Article
- Synaptic Clustering and Memory Formation.Frontiers in molecular neuroscience · 2019Review
- Microtopography of fear memory consolidation and extinction retrieval within prefrontal cortex and amygdala.Psychopharmacology · 2019Article
- Contextual Fear Conditioning Alter Microglia Number and Morphology in the Rat Dorsal Hippocampus.Frontiers in cellular neuroscience · 2019Article
- Functional Neuronal Topography: A Statistical Approach to Micro Mapping Neuronal Location.Frontiers in neural circuits · 2018Article
- Editorial: How Fear and Stress Shape the Mind.Frontiers in behavioral neuroscience · 2016Article
- Pre-Training Reversible Inactivation of the Basal Amygdala (BA) Disrupts Contextual, but Not Auditory, Fear Conditioning, in Rats.PloS one · 2015Article
- Analysis of kinase gene expression in the frontal cortex of suicide victims: implications of fear and stress.Frontiers in behavioral neuroscience · 2011Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the physical encoding of a memory (the engram) is a fundamental question in neuroscience. Although it has been established that the lateral amygdala is a key site for encoding associative fear memory, it is currently unclear whether the spatial distribution of neurons encoding a given memory is random or stable. Here we used spatial principal components analysis to quantify the topography of activated neurons, in a select region of the lateral amygdala, from rat brains encoding a Pavlovian conditioned fear memory. Our results demonstrate a stable, spatially patterned organization of amygdala neurons are activated during the formation of a Pavlovian conditioned fear memory. We suggest that this stable neuronal assembly constitutes a spatial dimension of the engram.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.