ArticlePloS one2011
IκB kinase β regulates epithelium migration during corneal wound healing.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.Investigative ophthalmology & visual science · 2025Article
- MicroRNAs Expression in Response to rhNGF in Epithelial Corneal Cells: Focus on Neurotrophin Signaling Pathway.International journal of molecular sciences · 2022Article
- The Role of SKQ1 (Visomitin) in Inflammation and Wound Healing of the Ocular Surface.Ophthalmology and therapy · 2019Article
- The role of corneal stroma: A potential nutritional source for the cornea.Journal of nature and science · 2017Article
- Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone.American journal of physiology. Lung cellular and molecular physiology · 2016Article
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- The effects of acacia honey on in vitro corneal abrasion wound healing model.BMC cell biology · 2015Article
- IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Oncoprotein E7 from beta human papillomavirus 38 induces formation of an inhibitory complex for a subset of p53-regulated promoters.Journal of virology · 2013Article
- Epidermal growth factor (EGF)-induced corneal epithelial wound healing through nuclear factor κB subtype-regulated CCCTC binding factor (CTCF) activation.The Journal of biological chemistry · 2013Article
- Interactions between NF-κB and SP3 connect inflammatory signaling with reduced FGF-10 expression.The Journal of biological chemistry · 2013Article
- Accelerated in vitro degradation of optically clear low-β sheet silk films by enzyme-mediated pretreatment.JAMA ophthalmology · 2013Article
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- Differentially expressed wound healing-related microRNAs in the human diabetic cornea.PloS one · 2013Article
- Accelerated In Vitro Degradation of Optically Clear LowTranslational vision science & technology · 2013Article
- The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair.PloS one · 2013Article
- Temporal smad7 transgene induction in mouse epidermis accelerates skin wound healing.The American journal of pathology · 2011Article
- Gene Expression Profile of Vascular Endothelial Growth Factors (VEGFs) and Platelet-derived Growth Factors (PDGFs) in the Normal Cornea.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The IKKβ is known to regulate transcription factor NF-κB activation leading to inflammatory responses. Recent gene knockout studies have shown that IKKβ can orchestrate local inflammatory responses and regulate homeostasis of epithelial tissues. To investigate whether IKKβ has an intrinsic role in epithelial cells, we established an in vivo system in the immune privileged corneal epithelium. We generated triple transgenic Krt12(rtTA/rtTAt)/tet-O-Cre/Ikkβ(F/F) (Ikkβ(ΔCE/ΔCE)) mice by crossing the Krt12-rtTA knock-in mice, which express the reverse tetracycline transcription activator in corneal epithelial cells, with the tet-O-Cre and Ikkβ(F/F) mice. Doxycycline-induced IKKβ ablation occurred in corneal epithelial cells of triple transgenic Ikkβ(ΔCE/ΔCE) mice, but loss of IKKβ did not cause ocular abnormalities in fetal development and postnatal maintenance. Instead, loss of IKKβ significantly delayed healing of corneal epithelial debridement without affecting cell proliferation, apoptosis or macrophage infiltration. In vitro studies with human corneal epithelial cells (HCEpi) also showed that IKKβ was required for cytokine-induced cell migration and wound closure but was dispensable for cell proliferation. In both in vivo and in vitro settings, IKKβ was required for optimal activation of NF-κB and p38 signaling in corneal epithelial cells, and p38 activation is likely mediated through formation of an IKKβ-p38 protein complex. Thus, our studies in corneal epithelium reveal a previously un-recognized role for IKKβ in the control of epithelial cell motility and wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.