ArticlePloS one2011
High resolution genotyping of clinical Aspergillus flavus isolates from India using microsatellites.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Environmental and Phylogenetic Investigations of Aspergillus flavus Outbreak Linked to Contaminated Building Materials, Denmark, 2025.Emerging infectious diseases · 2026Article
- Genotypic and Phenotypic Investigation of Clinical Aspergillus isolates from Iran Indicates Nosocomial Transmission Events of Aspergillus flavus.Mycopathologia · 2025Article
- Molecular identification and antifungal susceptibility testing ofAfrican journal of laboratory medicine · 2025Article
- Short Tandem Repeat Genotyping of Medically Important Fungi: A Comprehensive Review of a Powerful Tool with Extensive Future Potential.Mycopathologia · 2024Review
- Clinical and Microbiological Characteristics of Culture-Positive, Influenza-Associated Pulmonary Aspergillosis: A Single-Center Study in Southern Taiwan, 2016-2019.Journal of fungi (Basel, Switzerland) · 2022Article
- Genetic and Phenotypic Characterization of in-Host Developed Azole-ResistantJournal of fungi (Basel, Switzerland) · 2021Article
- A Short-Tandem-Repeat Assay (Journal of clinical microbiology · 2021Article
- Molecular Markers Reveal Epidemiological Patterns and Evolutionary Histories of the Human PathogenicFrontiers in cellular and infection microbiology · 2021Review
- Invasive Aspergillosis byJournal of fungi (Basel, Switzerland) · 2019Review
- Microsatellite Typing and Resistance Mechanism Analysis of Voriconazole-ResistantAntimicrobial agents and chemotherapy · 2019Article
- Magnitude of Voriconazole Resistance in Clinical and Environmental Isolates of Aspergillus flavus and Investigation into the Role of Multidrug Efflux Pumps.Antimicrobial agents and chemotherapy · 2018Article
- Article
- Investigating Clinical Issues by Genotyping of Medically Important Fungi: Why and How?Clinical microbiology reviews · 2017Review
- Genetic Diversity andAntimicrobial agents and chemotherapy · 2017Article
- Microsatellite Typing of Aspergillus flavus Strains in a Tunisian Onco-hematology Unit.Mycopathologia · 2016Article
- A Solution to the Common Problem of the Synthesis and Applications of Hexachlorofluorescein Labeled Oligonucleotides.PloS one · 2016Article
- The potential hazards of Aspergillus sp. in foods and feeds, and the role of biological treatment: a review.Journal of microbiology (Seoul, Korea) · 2014Review
- Nutrient environments influence competition among Aspergillus flavus genotypes.Applied and environmental microbiology · 2013Article
- Azole preexposure affects the Aspergillus fumigatus population in patients.Antimicrobial agents and chemotherapy · 2012Article
- Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species.Antimicrobial agents and chemotherapy · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWorldwide, Aspergillus flavus is the second leading cause of allergic, invasive and colonizing fungal diseases in humans. However, it is the most common species causing fungal rhinosinusitis and eye infections in tropical countries. Despite the growing challenges due to A. flavus, the molecular epidemiology of this fungus has not been well studied. We evaluated the use of microsatellites for high resolution genotyping of A. flavus from India and a possible connection between clinical presentation and genotype of the involved isolate. METHODOLOGY/PRINCIPAL
findingsA panel of nine microsatellite markers were selected from the genome of A. flavus NRRL 3357. These markers were used to type 162 clinical isolates of A. flavus. All nine markers proved to be polymorphic displaying up to 33 alleles per marker. Thirteen isolates proved to be a mixture of different genotypes. Among the 149 pure isolates, 124 different genotypes could be recognized. The discriminatory power (D) for the individual markers ranged from 0.657 to 0.954. The D value of the panel of nine markers combined was 0.997. The multiplex multicolor approach was instrumental in rapid typing of a large number of isolates. There was no correlation between genotype and the clinical presentation of the infection. CONCLUSIONS/SIGNIFICANCE: There is a large genotypic diversity in clinical A. flavus isolates from India. The presence of more than one genotype in clinical samples illustrates the possibility that persons may be colonized by multiple genotypes and that any isolate from a clinical specimen is not necessarily the one actually causing infection. Microsatellites are excellent typing targets for discriminating between A. flavus isolates from various origins.
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