ArticlePloS one2011
Mitochondrial function is required for secretion of DAF-28/insulin in C. elegans.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations.Journal of advanced research · 2026Article
- Targeting TOMM40 and TOMM22 to Rescue Statin-Impaired Mitochondrial Function, Dynamics, and Mitophagy in Skeletal Myotubes.International journal of molecular sciences · 2025Article
- TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway.Molecular metabolism · 2024Article
- Gain of Function of Malate Dehydrogenase 2 and Familial Hyperglycemia.The Journal of clinical endocrinology and metabolism · 2022Observational
- Exosome mediated Tom40 delivery protects against hydrogen peroxide-induced oxidative stress by regulating mitochondrial function.PloS one · 2022Article
- Suppression of a core metabolic enzyme dihydrolipoamide dehydrogenase (Genes & diseases · 2021Article
- ENPL-1, theDevelopment (Cambridge, England) · 2020Article
- TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels.Cancers · 2020Article
- Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism.Nature cell biology · 2018Article
- Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans.Cell metabolism · 2016Article
- A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity.Aging cell · 2015Article
- The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging.Journal of Parkinson's disease and Alzheimer's disease · 2014Article
- Complex expression dynamics and robustness in C. elegans insulin networks.Genome research · 2013Article
- VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.PLoS genetics · 2013Article
- What model organisms and interactomics can reveal about the genetics of human obesity.Cellular and molecular life sciences : CMLS · 2012Review
- A directed RNAi screen based on larval growth arrest reveals new modifiers of C. elegans insulin signaling.PloS one · 2012Article
- Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies.European journal of nutrition · 2011Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While insulin signaling has been extensively studied in Caenorhabditis elegans in the context of ageing and stress response, less is known about the factors underlying the secretion of insulin ligands upstream of the insulin receptor. Activation of the receptor governs the decision whether to progress through the reproductive lifecycle or to arrest growth and enter hibernation. We find that animals with reduced levels of the mitochondrial outer membrane translocase homologue TOMM-40 arrest growth as larvae and have decreased insulin signaling strength. TOMM-40 acts as a mitochondrial translocase in C. elegans and in its absence animals fail to import a mitochondrial protein reporter across the mitochondrial membrane(s). Inactivation of TOMM-40 evokes the mitochondrial unfolded protein response and causes a collapse of the proton gradient across the inner mitochondrial membrane. Consequently these broadly dysfunctional mitochondria render an inability to couple food abundance to secretion of DAF-28/insulin. The secretion defect is not general in nature since two other neuropeptides, ANF::GFP and INS-22::VENUS, are secreted normally. RNAi against two other putative members of the TOMM complex give similar phenotypes, implying that DAF-28 secretion is sensitive to mitochondrial dysfunction in general. We conclude that mitochondrial function is required for C. elegans to secrete DAF-28/insulin when food is abundant. This modulation of secretion likely represents an additional level of control over DAF-28/insulin function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.