ArticleJournal of clinical neurology (Seoul, Korea)2010
Measurement of precuneal and hippocampal volumes using magnetic resonance volumetry in Alzheimer's disease.
Article in Journal of clinical neurology (Seoul, Korea), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Application of Unsupervised Clustering Methods to Alzheimer's Disease.Frontiers in computational neuroscience · 2019Pooled it
- Brain morphometry in former American football players: findings from the DIAGNOSE CTE research project.Brain : a journal of neurology · 2024Article
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- Self-supervised multimodal learning for group inferences from MRI data: Discovering disorder-relevant brain regions and multimodal links.NeuroImage · 2024Article
- MRI Segmentation and Classification of Human Brain Using Deep Learning for Diagnosis of Alzheimer's Disease: A Survey.Sensors (Basel, Switzerland) · 2020Review
- Sex Differences in the Complexity of Healthy Older Adults' Magnetoencephalograms.Entropy (Basel, Switzerland) · 2019Article
- The anteroposterior and primary-to-posterior limbic ratios as MRI-derived volumetric markers of Alzheimer's disease.Journal of the neurological sciences · 2017Article
- Cerebral Perfusion Changes after Acetyl-L-Carnitine Treatment in Early Alzheimer's Disease Using Single Photon Emission Computed Tomography.Dementia and neurocognitive disorders · 2017Article
- Electroencephalography-driven approach to prodromal Alzheimer's disease diagnosis: from biomarker integration to network-level comprehension.Clinical interventions in aging · 2016Article
- Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer's disease.Neuropsychiatric disease and treatment · 2015Article
- Electroencephalography reveals lower regional blood perfusion and atrophy of the temporoparietal network associated with memory deficits and hippocampal volume reduction in mild cognitive impairment due to Alzheimer's disease.Neuropsychiatric disease and treatment · 2015Article
- Theta and alpha EEG frequency interplay in subjects with mild cognitive impairment: evidence from EEG, MRI, and SPECT brain modifications.Frontiers in aging neuroscience · 2015Article
- Mild Cognitive Impairment: Structural, Metabolical, and Neurophysiological Evidence of a Novel EEG Biomarker.Frontiers in neurology · 2015Review
- Atrophy and lower regional perfusion of temporo-parietal brain areas are correlated with impairment in memory performances and increase of EEG upper alpha power in prodromal Alzheimer's disease.American journal of neurodegenerative disease · 2015Article
- Understanding early dementia: EEG, MRI, SPECT and memory evaluation.Translational neuroscience · 2015Article
- Usefulness of medial temporal lobe atrophy visual rating scale in detecting Alzheimer's disease: Preliminary study.Annals of Indian Academy of Neurology · 2013Article
- EEG upper/low alpha frequency power ratio relates to temporo-parietal brain atrophy and memory performances in mild cognitive impairment.Frontiers in aging neuroscience · 2013Article
- Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population.Age (Dordrecht, Netherlands) · 2012Article
- Adverse effects of 24 hours of sleep deprivation on cognition and stress hormones.Journal of clinical neurology (Seoul, Korea) · 2012Article
- Article
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9 authors.
Funding
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Abstract
background and purposeAlzheimer's disease (AD) is associated with structural alterations in the medial temporal lobe (MTL) and functional alterations in the posterior cortical region, especially in the early stages. However, it is unclear what mechanisms underlie these regional discrepancies or whether the posterior cortical hypometabolism reflects disconnection from the MTL lesion or is the result of local pathology. The precuneus, an area of the posteromedial cortex that is involved in the early stages of AD, has recently received a great deal of attention in functional neuroimaging studies. To assess the relationship between the precuneus and hippocampus in AD, we investigated the volumes of these two areas using a magnetic resonance volumetric method.
methodsTwenty-three subjects with AD and 14 healthy age-matched controls underwent T1-weighted three-dimensional volumetric brain magnetic resonance imaging. Volumetric measurements were performed in the precuneus and hippocampus.
resultsCompared to controls, AD patients exhibited a significant reduction in total precuneal volume, which was more prominent on the right side, and significant bilateral reductions in hippocampal volume. No correlation was found between the total volumes of the precuneus and hippocampus in the AD group.
conclusionsThese results suggest that volumetric measurements of both the precuneus and hippocampus are useful radiological indices for the diagnosis of AD. Furthermore, the lack of correlation is attributable to local pathology rather than being a secondary consequence of MTL pathology.
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