ArticleExperimental and clinical cardiology2010
Impaired oxidative phosphorylation in overtrained rat myocardium.
Article in Experimental and clinical cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Exercise Performance, Muscle Oxygen Extraction and Blood Cell Mitochondrial Respiration after Repeated-Sprint and Sprint Interval Training in Hypoxia: A Pilot Study.Journal of sports science & medicine · 2018Trial
- Multiple Organ Phenotype of Fatigue.Biomolecules · 2025Review
- Potential of Pumpkin Pulp Carotenoid Extract in the Prevention of Doxorubicin-Induced Cardiotoxicity.Pharmaceutics · 2025Article
- High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling.Frontiers in public health · 2023Article
- Phytochemicals and modulation of exercise-induced oxidative stress: a novel overview of antioxidants.American journal of translational research · 2022Review
- Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition.Life (Basel, Switzerland) · 2021Review
- Intramuscular mechanisms of overtraining.Redox biology · 2020Review
- Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia.Journal of cellular and molecular medicine · 2020Article
- Silibinin Alleviates the Learning and Memory Defects in Overtrained Rats Accompanying Reduced Neuronal Apoptosis and Senescence.Neurochemical research · 2019Article
- FVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise.Frontiers in physiology · 2016Article
- Inhibitory effect of tetramethylpyrazine preconditioning on overload training-induced myocardial apoptosis in rats.Chinese journal of integrative medicine · 2015Article
- Ergogenic effects of quercetin supplementation in trained rats.Journal of the International Society of Sports Nutrition · 2013Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was undertaken to characterize and review the changes in energy metabolism in rat myocardium in response to chronic exhaustive exercise. It was shown that a treadmill exercise program applied for six weeks led the rats into a state characterized by decreased performance, loss of body weight and enhanced muscle catabolism, indicating development of overtraining syndrome. Electron microscopy revealed disintegration of the cardiomyocyte structure, cellular swelling and appearance of peroxisomes. Respirometric assessment of mitochondria in saponin-permeabilized cells in situ revealed a decreased rate of oxidative phosphorylation (OXPHOS) due to diminished control over it by ADP and impaired functional coupling of adenylate kinase to OXPHOS. In parallel, reduced tissue content of cytochrome c was observed, which could limit the maximal rate of OXPHOS. The results are discussed with respect to relationships between the volume of work and corresponding energy metabolism. It is concluded that overtraining syndrome is not restricted to skeletal muscle but can affect cardiac muscle as well.
Indexed as
Identifiers
21264069PMC3016071W1923179681What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.