ArticleOptics express2011
Intrinsic optical signal imaging of glucose-stimulated insulin secreting β-cells.
Article in Optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Stimulus-evoked outer segment changes in rod photoreceptors.Journal of biomedical optics · 2016Article
- Intrinsic optical signal imaging of retinal physiology: a review.Journal of biomedical optics · 2015Review
- En face optical coherence tomography of transient light response at photoreceptor outer segments in living frog eyecup.Optics letters · 2013Article
- Dynamic intrinsic optical signal monitoring of electrically stimulated inner retinal neural response.Journal of modern optics · 2012Article
- Functional imaging of glucose-evoked rat islet activities using transient intrinsic optical signals.Journal of modern optics · 2012Article
- Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinas.Optics express · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Simultaneous monitoring of many functioning β-cells is essential for understanding β-cell dysfunction as an early event in the progression to diabetes. Intrinsic optical signal (IOS) imaging has been shown to allow high resolution detection of stimulus-evoked physiological responses in the retina and other neural tissues. In this paper, we demonstrate the feasibility of using IOS imaging for functional examination of insulin secreting INS-1 cells, a popular model for investigating diabetes associated β-cell dysfunction. Our experiments indicate that IOS imaging permits simultaneous monitoring of glucose-stimulated physiological responses in multiple cells with high spatial (sub-cellular) and temporal (sub-second) resolution. Rapid IOS image sequences revealed transient optical responses that had time courses tightly correlated with the glucose stimulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.