ArticlePediatric research2011
Mother's milk-induced Hsp70 expression preserves intestinal epithelial barrier function in an immature rat pup model.
Article in Pediatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- The Multiple Roles of Heat Shock Proteins in the Development of Inflammatory Bowel Disease.Current molecular medicine · 2025Review
- Effects of Ban Lian Zi Jin San on intestinal inflammation and barrier function of heat-stressed broilers.Poultry science · 2024Article
- Review
- Gestational age at birth influences protein and RNA content in human milk extracellular vesicles.Journal of extracellular biology · 2024Article
- Influence of Heat Stress on Poultry Growth Performance, Intestinal Inflammation, and Immune Function and Potential Mitigation by Probiotics.Animals : an open access journal from MDPI · 2022Review
- Hypoxia and heat stress affect epithelial integrity in a Caco-2/HT-29 co-culture.Scientific reports · 2021Article
- Identification of unknown acid-resistant genes of oral microbiotas in patients with dental caries using metagenomics analysis.AMB Express · 2021Article
- Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome-Metabolomics Analysis.Frontiers in immunology · 2021Article
- The Role of Polyphenols in Regulation of Heat Shock Proteins and Gut Microbiota in Weaning Stress.Oxidative medicine and cellular longevity · 2021Review
- Chronic heat stress regulates the relation between heat shock protein and immunity in broiler small intestine.Scientific reports · 2020Article
- Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis: The State of the Science.Clinics in perinatology · 2019Review
- Phorbol 12-Myristate 13-Acetate-Induced Changes in Chicken Enterocytes.Proteomics insights · 2019Article
- Dietary Nutrients and Bioactive Substances Modulate Heat Shock Protein (HSP) Expression: A Review.Nutrients · 2018Review
- Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2.Pediatric surgery international · 2018Article
- Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota.Nutrition reviews · 2016Review
- Effects of Lactobacillus johnsonii and Lactobacillus reuteri on gut barrier function and heat shock proteins in intestinal porcine epithelial cells.Physiological reports · 2015Article
- Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Intestinal alkaline phosphatase is protective to the preterm rat pup intestine.Journal of pediatric surgery · 2014Article
- Immunomodulatory effects of lactoferrin.Acta pharmacologica Sinica · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Preterm infants face many challenges in transitioning from the in utero to extrauterine environment while still immature. Failure of the preterm gut to successfully mature to accommodate bacteria and food substrate leads to significant morbidity such as neonatal necrotizing enterocolitis. The intestinal epithelial barrier plays a critical role in gut protection. Heat shock protein 70 (Hsp70) is an inducible cytoprotective molecule shown to protect the intestinal epithelium in adult models. To investigate the hypothesis that Hsp70 may be important for early protection of the immature intestine, Hsp70 expression was evaluated in intestine of immature rat pups. Data demonstrate that Hsp70 is induced by exposure to mother's milk. Hsp70 is found in mother's milk, and increased Hsp70 transcription is induced by mother's milk. This Hsp70 colocalizes with the tight junction protein ZO-1. Mother's milk-induced Hsp70 may contribute to maintenance of barrier function in the face of oxidant stress. Further understanding of the means by which mother's milk increases Hsp70 in the ileum will allow potential means of strengthening the intestinal barrier in at-risk preterm infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.