ArticleAnnals of plastic surgery2011
Silk fibroin conduits: a cellular and functional assessment of peripheral nerve repair.
Article in Annals of plastic surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Aligned silk fibroin fiber conduits with enhanced capability for guiding peripheral nerve repair.European journal of medical research · 2025Article
- Silk Fibroin Methacrylation: Chemical Synthesis to Biomechanical Optimization in Tissue Engineering.ACS biomaterials science & engineering · 2025Review
- Peripheral nerve regeneration using a bioresorbable silk fibroin-based artificial nerve conduit fabricated via a novel freeze-thaw process.Scientific reports · 2025Article
- Silk fibroin carriers with sustained release capacity for treating neurological diseases.Frontiers in pharmacology · 2023Review
- Nerve guidance conduit design based on self-rolling tubes.Materials today. Bio · 2020Article
- Anastomotic stoma coated with chitosan film as a betamethasone dipropionate carrier for peripheral nerve regeneration.Neural regeneration research · 2018Article
- Partially oxidized polyvinyl alcohol conduitfor peripheral nerve regeneration.Scientific reports · 2018Article
- The effect of four types of artificial nerve graft structures on the repair of 10-mm rat sciatic nerve gap.Journal of biomedical materials research. Part A · 2017Article
- In vivo bioresponses to silk proteins.Biomaterials · 2015Review
- A New Preparation Method for Anisotropic Silk Fibroin Nerve Guidance Conduits and Its Evaluation In Vitro and in a Rat Sciatic Nerve Defect Model.Tissue engineering. Part C, Methods · 2015Article
- The behavior of neuronal cells on tendon-derived collagen sheets as potential substrates for nerve regeneration.Biomaterials · 2014Article
- Neural responses to electrical stimulation on patterned silk films.Journal of biomedical materials research. Part A · 2013Article
- A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs.Biomaterials · 2012Article
- Allotransplanted neurons used to repair peripheral nerve injury do not elicit overt immunogenicity.PloS one · 2012Article
- Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Silk fibroin conduits were designed with appropriate porosity for peripheral nerve repair. The aim of this work was to use these conduits to examine cell inflammatory responses and functional recovery in a sciatic nerve defect model. A total of 45 randomized Lewis rats were used to create an 8-mm defect bridged by a silk guide, commercial collagen guide, or an autograft. After 1, 4, and 8 weeks, macrophage recruitment, percentage of newly formed collagen, number of myelinated axons, and gastrocnemius muscle mass were evaluated. Following 8 weeks, ED1+ cells in autograft and silk conduits decreased to <1% and 17% of week 1 values, respectively. Collagen formation revealed no difference for all measured time points, suggesting a similar foreign body response. Myelinated axon counts within the silk guide revealed a greater number of proximal spouts and distal connections than collagen guides. Gastrocnemius weights demonstrated a 27% decrease between silk and autografts after 8 weeks. This study demonstrates that, in addition to tailorable degradation rates, our silk conduits possess a favorable immunogenicity and remyelination capacity for nerve repair.
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Registered trials
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