ArticleThe American journal of surgical pathology2011
Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.
Article in The American journal of surgical pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- IgM and IgG1 B cell receptors differentially affect B cell fates and dictate the pathogenesis of mature B cell lymphomas.Science advances · 2025Article
- The Diagnostic and Treatment Challenges of Concomitant Mantle Cell Lymphoma and IgM Myeloma.European journal of case reports in internal medicine · 2022Article
- The pathologic diagnosis of mantle cell lymphoma.Histology and histopathology · 2021Review
- Increased complexity of t(11;14) rearrangements in plasma cell neoplasms compared with mantle cell lymphoma.Genes, chromosomes & cancer · 2021Article
- AL amyloidosis with a localized B cell neoplasia.Virchows Archiv : an international journal of pathology · 2019Article
- Marginal zone B-cell lymphoma mimicking extramedullary plasmacytoma and the clinical outcome after treatment.Archives of medical science : AMS · 2017Article
- The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing.Virchows Archiv : an international journal of pathology · 2016Review
- Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study.Human pathology · 2013Review
- New diagnosis of multiple myeloma in a patient with mantle cell lymphoma: Shared genetic factors or simple coincidence?Leukemia research reports · 2012Article
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Authors and funding
22 authors at 9 institutions in 5 countries.
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Abstract
The normal counterparts of mantle cell lymphoma (MCL) are naive, quiescent B cells that have not been processed through the germinal center (GC). For this reason, although lymphomas arising from GC or post-GC B cells often exhibit plasmacytic differentiation, MCL rarely presents with plasmacytic features. Seven cases of MCL with a monotypic plasma cell (PC) population were collected from 6 centers and were studied by immunohistochemistry, fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms analysis, capillary gel electrophoresis, and restriction fragment length polymorphism of immunoglobulin heavy chain analysis of microdissections of each of the MCL and PC populations to assess their clonal relationship. The clinical presentation was rather unusual compared with typical MCL, with 2 cases arising from the extranodal soft tissues of the head. All MCL cases were morphologically and immunohistochemically typical, bearing the t(11;14)(q13;q32). In all cases, the PC population was clonal. In 5 of the 7 cases, the MCL and PC clones showed identical restriction fragments, indicating a common clonal origin of the neoplastic population. The 2 cases with clonal diversity denoted the coexistence of 2 different tumors in a composite lymphoma/PC neoplasm. Our findings suggest that MCL can present with a PC component that is often clonally related to the lymphoma, representing a rare but unique biological variant of this tumor.
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