ArticleNeurology2011
Distinguishing 3 classes of corpus callosal abnormalities in consanguineous families.
Article in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Radiogenomics of congenital brain malformations: Linking embryology, genetics, and imaging.Neuroradiology · 2026Review
- Brain MRI findings in paediatric genetic disorders associated with white matter abnormalities.Developmental medicine and child neurology · 2025Article
- Assessing the Agreement Between Diffusion Tension Imaging (DTI) and T2-Weighted MRI Sequence for Biometry of the Fetal Corpus Callosum.Diagnostics (Basel, Switzerland) · 2024Article
- Fetal MRI Analysis of Corpus Callosal Abnormalities: Classification, and Associated Anomalies.Diagnostics (Basel, Switzerland) · 2024Article
- Acquired hump of the corpus callosum: a rare morphologic complication after CSF shunting.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Article
- Fetal Neurology: From Prenatal Counseling to Postnatal Follow-Up.Diagnostics (Basel, Switzerland) · 2022Review
- Distinguishing 3 Classes of Corpus Callosal Abnormalities in Consanguineous Families.Neurology · 2022Article
- Chromosomal Microarray Analysis in Pregnancies With Corpus Callosum or Posterior Fossa Anomalies.Neurology. Genetics · 2021Article
- The splenium of the corpus callosum: embryology, anatomy, function and imaging with pathophysiological hypothesis.Neuroradiology · 2020Review
- Mutations in the microtubule-associated protein MAP11 (C7orf43) cause microcephaly in humans and zebrafish.Brain : a journal of neurology · 2019Article
- Pediatric brain MRI part 1: basic techniques.Pediatric radiology · 2017Review
- Clinical manifestations in children and adolescents with corpus callosum abnormalities.Journal of neurology · 2016Article
- A novel 2q37 microdeletion containing human neural progenitors genes including STK25 results in severe developmental delay, epilepsy, and microcephaly.American journal of medical genetics. Part A · 2015Article
- Morphometric variability of neuroimaging features in children with agenesis of the corpus callosum.BMC neurology · 2015Article
- Whole-exome sequencing identifies mutated c12orf57 in recessive corpus callosum hypoplasia.American journal of human genetics · 2013Article
- Recurrent hypothermia with hyperhidrosis in two siblings: familial Shapiro syndrome variant.Journal of neurology · 2012Article
- Successful treatment of hypodipsic/adipsic hypernatremia in a cat with lobar holoprosencephaly using oral desmopressin.JFMS open reportsArticle
- Corpus callosal abnormalities in dogs.Journal of veterinary internal medicineArticle
- Magnetic Resonance Imaging Findings in Fetal Corpus Callosal Developmental Abnormalities: A Pictorial Essay.Journal of pediatric neurosciencesReview
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe sought to create a classification system for pediatric corpus callosal abnormalities (CCA) based upon midline sagittal brain MRI. We used the term CCA for patients with structural variants of the corpus callosum, excluding patients with interhemispheric cyst variant or pure dysplasia without hypoplasia. Currently, no system exists for nonsyndromic forms of CCA, and attempts to create such a system have been hampered by highly variable morphology in patients with sporadic CCA. We reasoned that any useful strategy should classify affected family members within the same type, and that phenotypic variability should be minimized in patients with recessive disease.
methodsWe focused recruitment toward multiplex consanguineous families, ascertained 30 patients from 19 consanguineous families, and analyzed clinical features together with brain imaging.
resultsWe identified 3 major CCA classes, including hypoplasia, hypoplasia with dysplasia, and complete agenesis. Affected individuals within a given multiplex family usually displayed the same variant of the class of abnormality and they always displayed the same class of abnormality within each family, or they displayed complete agenesis. The system was validated among a second cohort of 10 sporadic patients with CCA.
conclusionsThe data suggest that complete agenesis may be a common end-phenotype, and implicate multiple overlapping pathways in the etiology of CCA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.