ArticleThe Journal of cell biology2011
Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure.
Article in The Journal of cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The cell-adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth.Development (Cambridge, England) · 2025Article
- Too old for hide-and-seek; cell maturation reveals hidden apical junctional organization.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The surface ectoderm exhibits spatially heterogenous tension that correlates with YAP localisation during spinal neural tube closure in mouse embryos.Cells & development · 2023Article
- JNK signaling and integrins cooperate to maintain cell adhesion during epithelial fusion inFrontiers in cell and developmental biology · 2023Article
- SCAR/WAVE complex recruitment to a supracellular actomyosin cable by myosin activators and a junctional Arf-GEF duringMolecular biology of the cell · 2022Article
- Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using aG3 (Bethesda, Md.) · 2020Article
- Neuronal immunoglobulin superfamily cell adhesion molecules in epithelial morphogenesis: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Orchestrating morphogenesis: building the body plan by cell shape changes and movements.Development (Cambridge, England) · 2020Review
- Differential Expression of a Classic Cadherin Directs Tissue-Level Contractile Asymmetry during Neural Tube Closure.Developmental cell · 2019Article
- Dynamic interplay of cell fate, polarity and force generation in ascidian embryos.Current opinion in genetics & development · 2018Review
- Identifying Genetic Players in Cell Sheet Morphogenesis Using aG3 (Bethesda, Md.) · 2018Article
- The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis.The Journal of cell biology · 2018Article
- Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System.Annual review of cell and developmental biology · 2017Review
- Smurf Downregulates Echinoid in the Amnioserosa To RegulateGenetics · 2017Article
- Article
- Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.Developmental cell · 2017Review
- Remodeling Tissue Interfaces and the Thermodynamics of Zipping during Dorsal Closure in Drosophila.Biophysical journal · 2015Article
- Article
- Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms.Cytoskeleton (Hoboken, N.J.) · 2015Review
- Ephrin-Eph signaling in embryonic tissue separation.Cell adhesion & migration · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
During Drosophila melanogaster dorsal closure, lateral sheets of embryonic epidermis assemble an actomyosin cable at their leading edge and migrate dorsally over the amnioserosa, converging at the dorsal midline. We show that disappearance of the homophilic cell adhesion molecule Echinoid (Ed) from the amnioserosa just before dorsal closure eliminates homophilic interactions with the adjacent dorsal-most epidermal (DME) cells, which comprise the leading edge. The resulting planar polarized distribution of Ed in the DME cells is essential for the localized accumulation of actin regulators and for actomyosin cable formation at the leading edge and for the polarized localization of the scaffolding protein Bazooka/PAR-3. DME cells with uniform Ed fail to assemble a cable and protrude dorsally, suggesting that the cable restricts dorsal migration. The planar polarized distribution of Ed in the DME cells thus provides a spatial cue that polarizes the DME cell actin cytoskeleton, defining the epidermal leading edge and establishing its contractile properties.
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Registered trials
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