ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2011
Drug formulations that require less than 0.1 mL of stock solution to prepare doses for infants and children.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine.British journal of clinical pharmacology · 2017Trial
- Gravimetric compounding workflow technology insights for pharmacists and pharmacy technicians.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2025Article
- Accuracy of antibiotic concentrations in drug dispensing in neonates: a laboratory-based study.BMJ paediatrics open · 2023Article
- Development of Guidelines for Accurate Measurement of Small Volume Parenteral Products Using Syringes.Hospital pharmacy · 2021Article
- Accuracy of intravenous and enteral preparations involving small volumes for paediatric use: a review.European journal of hospital pharmacy : science and practice · 2018Review
- Discontinuation of paediatric injectable digoxin: A loss for optimal drug therapy in children.Paediatrics & child health · 2016Article
- Medicine preparation errors in ten Spanish neonatal intensive care units.European journal of pediatrics · 2016Observational
- Challenges Associated with Route of Administration in Neonatal Drug Delivery.Clinical pharmacokinetics · 2016Review
- Neonatal drug therapy: The first frontier of therapeutics for children.Clinical pharmacology and therapeutics · 2015Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intravenous doses of medications require formulations that permit accurate preparation and administration. Current equipment does not permit accurate measurement of volumes less than 0.1 mL. In a study of four hypothetical standard pediatric patients, we found that 28 common medications required less than 0.1 mL of available formulation to prepare the dose. In a clinical study of actual use in a pediatric intensive care unit (ICU), 5245 (7.4%) of 71 218 intravenous doses required preparation from less than 0.1 mL of stock solution. For 28.5% of the 1531 ICU admissions, at least one dose was prepared from a volume of less than 0.1 mL. Our findings identify a substantial source of dosing error. Correction will require revision of preparation methods, regulatory requirements and manufacturing practices.
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