ArticleAmerican journal of epidemiology2011
Validation of a small set of ancestral informative markers for control of population admixture in African Americans.
Article in American journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study of age at menarche in African-American women.Human molecular genetics · 2013Pooled it
- Replication of genetic loci for sarcoidosis in US black women: data from the Black Women's Health Study.Human genetics · 2013Trial
- Associations between genetic ancestry and allergic outcomes at 10 years among Black children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Research on Health Disparities: Strategies and Findings From the Black Women's Health Study.American journal of epidemiology · 2023Article
- Genetic Variants inFrontiers in oncology · 2021Article
- Population Stratification in Genetic Association Studies.Current protocols in human genetics · 2017Review
- Single nucleotide variants in metastasis-related genes are associated with breast cancer risk, by lymph node involvement and estrogen receptor status, in women with European and African ancestry.Molecular carcinogenesis · 2017Article
- Article
- FASN, dietary fat intake, and risk of uterine leiomyomata in the Black Women's Health Study.Fertility and sterility · 2016Article
- An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression.Human molecular genetics · 2016Article
- Genetic variants in the mTOR pathway and interaction with body size and weight gain on breast cancer risk in African-American and European American women.Cancer causes & control : CCC · 2016Article
- Population Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data.Frontiers in genetics · 2016Article
- Admixture mapping of genetic variants for uterine fibroids.Journal of human genetics · 2015Article
- Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.International journal of cancer · 2015Article
- Polymorphisms in vitamin D-related genes and risk of uterine leiomyomata.Fertility and sterility · 2014Article
- Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry.International journal of cancer · 2014Article
- Variants of estrogen-related genes and breast cancer risk in European and African American women.Endocrine-related cancer · 2014Article
- Socioeconomic status and lung cancer: unraveling the contribution of genetic admixture.American journal of public health · 2013Article
- Is the observed association between dairy intake and fibroids in African Americans explained by genetic ancestry?American journal of epidemiology · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Confounding due to population stratification is a potential source of concern in population-based genetic association studies, particularly in recently admixed populations such as African Americans. Several methods have been developed to control for population stratification in the context of genome-wide association studies. Because these approaches require thousands of genotypes from genetic markers, they are not well suited to be used in genetic association analyses without genome-wide data. An alternative approach to control for population stratification is to estimate admixture proportions by using ancestral informative markers (AIMs). The authors evaluated whether a relatively small number of AIMs would be sufficient to estimate ancestral proportions in African Americans. They first estimated European admixture proportions in 1,757 subjects from the Black Women's Health Study (1995-2009) by genotyping an admixture panel of 1,373 AIMs; they then compared these results with those obtained using smaller sets of AIMs. The authors found that just 30 AIMs are needed to obtain very high correlation of estimates with the entire set (r = 0.89; P < 0.0001). A set of 200 AIMs gave an almost perfect correlation with the entire set (r = 0.98; P < 0.0001). These results show that a small number of AIMs are sufficiently precise to estimate European admixture in African Americans.
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