ArticleProceedings of the National Academy of Sciences of the United States of America2011
2D luminescence imaging of pH in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Evidence of Traditional Medicines in Modulating the Immune Response and Diabetic Wound Healing.Current topics in medicinal chemistry · 2026Pooled it
- The Role of Skin Surface pH in Age Associated Pruritus: Mechanistic and Clinical Insights.American journal of clinical dermatology · 2026Review
- Intracellular pH dynamics promotes zebrafish larval tail regeneration.bioRxiv : the preprint server for biology · 2026Article
- Fluorescent Polymeric Nanofibers as Ratiometric Multiplexed Skin Sensors of pH and Oxygen.Advanced healthcare materials · 2026Article
- Functionalized hydrogel sequentially deliver tannic acid and bioactive probiotics for radiation-induced skin injury.Materials today. Bio · 2026Article
- Interactions Between Active Matters and Endogenous Fields.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Novel Diffuse Midline Glioma-on-Chip Recapitulating Tumor Biophysical Microenvironment to Assess the Heterogeneity of Response to Therapies.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Simulating the Skin Permeation Process of Ionizable Molecules.Journal of chemical information and modeling · 2024Article
- Kick-Starting Wound Healing: A Review of Pro-Healing Drugs.International journal of molecular sciences · 2024Review
- A time-dependent survival analysis for early prognosis of chronic wounds by monitoring wound alkalinity.International wound journal · 2023Article
- Recent advances in responsive hydrogels for diabetic wound healing.Materials today. Bio · 2023Review
- Expression of pH-Sensitive TRPC4 in Common Skin Tumors.International journal of molecular sciences · 2023Article
- Optical pH Monitoring in Microdroplet Platforms for Live Cell Experiments Using Colloidal Surfactants.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- A wound alkalinity measurement to predict non-healing wound outcomes.Journal of wound care · 2022Article
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- NiFrontiers in molecular biosciences · 2022Article
- Thermotropic Liquid Crystals for Temperature Mapping.Frontiers in bioengineering and biotechnology · 2022Article
- Catalase Activity in Keratinocytes, Stratum Corneum, and Defatted Algae Biomass as a Potential Skin Care Ingredient.Biomedicines · 2021Article
- High-resolution spatiotemporal pHCancer & metabolism · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Luminescence imaging of biological parameters is an emerging field in biomedical sciences. Tools to study 2D pH distribution are needed to gain new insights into complex disease processes, such as wound healing and tumor metabolism. In recent years, luminescence-based methods for pH measurement have been developed. However, for in vivo applications, especially for studies on humans, biocompatibility and reliability under varying conditions have to be ensured. Here, we present a referenced luminescent sensor for 2D high-resolution imaging of pH in vivo. The ratiometric sensing scheme is based on time-domain luminescence imaging of FITC and ruthenium(II)tris-(4,7-diphenyl-1,10-phenanthroline). To create a biocompatible 2D sensor, these dyes were bound to or incorporated into microparticles (aminocellulose and polyacrylonitrile), and particles were immobilized in polyurethane hydrogel on transparent foils. We show sensor precision and validity by conducting in vitro and in vivo experiments, and we show the versatility in imaging pH during physiological and chronic cutaneous wound healing in humans. Implementation of this technique may open vistas in wound healing, tumor biology, and other biomedical fields.
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