ArticleProceedings of the National Academy of Sciences of the United States of America2011
Genome and transcriptome analyses of the mountain pine beetle-fungal symbiont Grosmannia clavigera, a lodgepole pine pathogen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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98 citing papers in PubMed, 226 citations in OpenAlex.
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- From beginning to end: the synecology of tree-killing bark beetles, fungi, and trees.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Pine monoterpenes drive growth, competition, and volatile metabolism of symbiotic fungi associated with the mountain pine beetle.FEMS microbiology letters · 2026Article
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- Advancing Semiochemical Tools for Mountain Pine Beetle Management:Metabolites · 2025Article
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- Distinct assembly processes of intestinal and non-intestinal microbes of bark beetles from clues of metagenomic insights.Scientific reports · 2025Article
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- Characterization of Terpenoids from the Ambrosia Beetle Symbiont and Laurel Wilt PathogenJournal of fungi (Basel, Switzerland) · 2023Article
- A Pine in Distress: How Infection by Different Pathogenic Fungi Affect Lodgepole Pine Chemical Defenses.Microbial ecology · 2023Article
- Genome and transcriptome ofiScience · 2023Article
- A Review of the Host Plant Location and Recognition Mechanisms of Asian Longhorn Beetle.Insects · 2023Review
- Isolation and characterization of gut bacteria associated with the degradation of host-specific terpenoids in Pagiophloeus tsushimanus (Coleoptera: Curculionidae) larvae.Journal of insect science (Online) · 2023Article
- Insight into the genomes of dominant yeast symbionts of European spruce bark beetle,Frontiers in microbiology · 2023Article
- Host Defense Metabolites Alter the Interactions between a Bark Beetle and its Symbiotic Fungi.Microbial ecology · 2022Article
- Phylogeny of Regulators of G-Protein Signaling Genes inMicroorganisms · 2022Article
- Molecular basis of cycloheximide resistance in the Ophiostomatales revealed.Current genetics · 2022Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In western North America, the current outbreak of the mountain pine beetle (MPB) and its microbial associates has destroyed wide areas of lodgepole pine forest, including more than 16 million hectares in British Columbia. Grosmannia clavigera (Gc), a critical component of the outbreak, is a symbiont of the MPB and a pathogen of pine trees. To better understand the interactions between Gc, MPB, and lodgepole pine hosts, we sequenced the ∼30-Mb Gc genome and assembled it into 18 supercontigs. We predict 8,314 protein-coding genes, and support the gene models with proteome, expressed sequence tag, and RNA-seq data. We establish that Gc is heterothallic, and report evidence for repeat-induced point mutation. We report insights, from genome and transcriptome analyses, into how Gc tolerates conifer-defense chemicals, including oleoresin terpenoids, as they colonize a host tree. RNA-seq data indicate that terpenoids induce a substantial antimicrobial stress in Gc, and suggest that the fungus may detoxify these chemicals by using them as a carbon source. Terpenoid treatment strongly activated a ∼100-kb region of the Gc genome that contains a set of genes that may be important for detoxification of these host-defense chemicals. This work is a major step toward understanding the biological interactions between the tripartite MPB/fungus/forest system.
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