ArticleProceedings of the National Academy of Sciences of the United States of America2011
Interspecies pheromone signaling promotes biofilm formation and same-sex mating in Candida albicans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 58 citations in OpenAlex.
- The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis.PLoS pathogens · 2025Article
- On the evolution of variation in sexual reproduction through the prism of eukaryotic microbes.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Peptide Variant Detection by a Living Yeast Biosensor via an Epitope-Selective Protease.Biodesign research · 2023Article
- Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- DNA damage response of major fungal pathogen Candida glabrata offers clues to explain its genetic diversity.Current genetics · 2021Review
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- The Impact of Gene Dosage and Heterozygosity on The Diploid PathobiontJournal of fungi (Basel, Switzerland) · 2019Review
- ThemBio · 2019Article
- New approaches in bioprocess-control: Consortium guidance by synthetic cell-cell communication based on fungal pheromones.Engineering in life sciences · 2018Review
- Pheromone expression reveals putative mechanism of unisexuality in a saprobic ascomycete fungus.PloS one · 2018Article
- Parasex Generates Phenotypic DiversityGenetics · 2017Article
- Negative regulation of filamentous growth in Candida albicans by Dig1p.Molecular microbiology · 2017Article
- Biofilm formation in enterococci: genotype-phenotype correlations and inhibition by vancomycin.Scientific reports · 2017Article
- Fungal Sex: The Basidiomycota.Microbiology spectrum · 2017Review
- Structure-Activity Relationship of α Mating Pheromone from the Fungal PathogenThe Journal of biological chemistry · 2017Article
- Article
- Budding off: bringing functional genomics to Candida albicans.Briefings in functional genomics · 2016Review
- Deubiquitinase Ubp5 Is Required for the Growth and Pathogenicity of Cryptococcus gattii.PloS one · 2016Article
- The parasexual lifestyle of Candida albicans.Current opinion in microbiology · 2015Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The opportunistic pathogen Candida albicans undergoes a parasexual mating cycle in which cells must switch from the conventional "white" form to the alternative "opaque" form to become mating competent. Pheromones secreted by opaque cells induce the formation of polarized mating projections and result in cell-cell conjugation. In contrast, white cells are unable to undergo mating, but can still respond to pheromone by expression of adhesion genes that promote biofilm formation. In this study, we have analyzed the dual ability of pheromones to activate mating by opaque cells and biofilm formation by white cells. We first show that there is considerable plasticity in interactions between the α pheromone and its receptor, Ste2, by analysis of analogs of the α pheromone. Significantly, substituted forms of α pheromone can induce a response in opaque cells and this is sufficient to drive same-sex a-a cell fusion and homothallic mating. In addition, pheromone analogs were able to induce adhesion and biofilm formation in white cells of C. albicans. Because of the observed plasticity in pheromone signaling, we subsequently tested putative pheromones from multiple Candida species and identified nonnative ligands that can induce self-mating and biofilm responses in C. albicans. Our findings demonstrate that environmental signals can initiate C. albicans parasexual reproduction and biofilm formation, and highlight the role of the pheromone-signaling apparatus in mediating these functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.