ArticleMolecular and cellular biology2011
Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Cdc14 phosphatase counteracts Cdk-dependent Dna2 phosphorylation to inhibit resection during recombinational DNA repair.Nature communications · 2023Article
- Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.The EMBO journal · 2023Article
- Conservation of Cdc14 phosphatase specificity in plant fungal pathogens: implications for antifungal development.Scientific reports · 2020Article
- Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins.International journal of molecular sciences · 2020Review
- Effects of chromosome 9 inversion on IVF/ICSI: A 7-year retrospective cohort study.Molecular genetics & genomic medicine · 2019Article
- Review
- CDC14A phosphatase is essential for hearing and male fertility in mouse and human.Human molecular genetics · 2018Article
- From Oxidative Stress Damage to Pathways, Networks, and Autophagy via MicroRNAs.Oxidative medicine and cellular longevity · 2018Article
- Identification of genome-wide SNP-SNP interactions associated with important traits in chicken.BMC genomics · 2017Article
- Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases.International journal of molecular sciences · 2017Review
- The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.Nature communications · 2017Article
- Stabilization of the metaphase spindle by Cdc14 is required for recombinational DNA repair.The EMBO journal · 2017Article
- Novel regional age-associated DNA methylation changes within human common disease-associated loci.Genome biology · 2016Article
- Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.Molecular and cellular biology · 2015Article
- Article
- The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability.Molecular cell · 2014Article
- The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation.Genetics · 2014Article
- Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis.EMBO molecular medicine · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The Cdc14 dual-specificity phosphatase plays a key role in the mitotic exit of budding yeast cells. Mammals have two homologues, Cdc14a and Cdc14b. Unlike the yeast counterpart, neither Cdc14a nor Cdc14b seems to be essential for mitotic exit. To determine the physiological function of Cdc14b, we generated mice deficient in the phosphatase. The mutant mice were viable and did not display overt abnormalities. However, these mice developed signs of aging at much younger ages than the wild-type mice. At the cellular level, the Cdc14b-deficient mouse embryonic fibroblasts (MEFs) grew more slowly than the controls at later passages as a result of increased rates of senescence. Consistent with these premature-aging phenotypes, Cdc14b-deficient cells accumulated more endogenous DNA damage than the wild-type cells, and more Cdc14b-deficient MEFs entered senescence than control MEFs in response to exogenous DNA damage. However, no deficiencies in DNA damage checkpoint response were detected in Cdc14b mutant cells, suggesting that the function of Cdc14b is required for efficient DNA damage repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.