ArticleMolecular and cellular biology2011
Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 57 citations in OpenAlex.
- Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation.Immunity · 2023Article
- SWI/SNF chromatin remodelers in prostate cancer progression.Frontiers in epigenetics and epigenomics · 2023Review
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- Establishment and function of chromatin modification at enhancers.Open biology · 2020Article
- In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice.Nature communications · 2020Article
- Transcriptional Activation of Matricellular Protein Spondin2 (SPON2) by BRG1 in Vascular Endothelial Cells Promotes Macrophage Chemotaxis.Frontiers in cell and developmental biology · 2020Article
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- Immuno-suppressive function of nucleus-transducible BAF57-ΔPH in T cell activation via degradation of endogenous BAF57.International journal of hematology · 2018Article
- 5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells.PLoS genetics · 2017Article
- Arabidopsis SWI/SNF chromatin remodeling complex binds both promoters and terminators to regulate gene expression.Nucleic acids research · 2017Article
- Enhancer deregulation in cancer and other diseases.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- The Swi3 protein plays a unique role in regulating respiration in eukaryotes.Bioscience reports · 2016Article
- Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.The Journal of clinical investigation · 2016Article
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- ARGONAUTE2 cooperates with SWI/SNF complex to determine nucleosome occupancy at human Transcription Start Sites.Nucleic acids research · 2015Article
- Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis.Genome research · 2014Article
- Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation.Nature communications · 2014Article
- Transcriptional regulation of T helper type 2 differentiation.Immunology · 2014Review
- p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells.Development (Cambridge, England) · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
T helper cell differentiation and activation require specific transcriptional programs accompanied by changes in chromatin structure. However, little is known about the chromatin remodeling enzymes responsible. We performed genome-wide analysis to determine the general principles of BRG1 binding, followed by analysis of specific genes to determine whether these general rules were typical of key T cell genes. We found that binding of the remodeling protein BRG1 was programmed by both lineage and activation signals. BRG1 binding positively correlated with gene activity at protein-coding and microRNA (miRNA) genes. BRG1 binding was found at promoters and distal regions, including both novel and previously validated distal regulatory elements. Distal BRG1 binding correlated with expression, and novel distal sites in the Gata3 locus possessed enhancer-like activity, suggesting a general role for BRG1 in long-distance gene regulation. BRG1 recruitment to distal sites in Gata3 was impaired in cells lacking STAT6, a transcription factor that regulates lineage-specific genes. Together, these findings suggest that BRG1 interprets both differentiation and activation signals and plays a causal role in gene regulation, chromatin structure, and cell fate. Our findings suggest that BRG1 binding is a useful marker for identifying active cis-regulatory regions in protein-coding and miRNA genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.