ArticleNeuron2011
In vivo time-lapse imaging and serial section electron microscopy reveal developmental synaptic rearrangements.
Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
- An Algorithm Based on a Cable-Nernst Planck Model Predicting Synaptic Activity throughout the Dendritic Arbor with Micron Specificity.Neuroinformatics · 2023Article
- Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons.eLife · 2021Article
- Niwaki Instead of Random Forests: Targeted Serial Sectioning Scanning Electron Microscopy With Reimaging Capabilities for Exploring Central Nervous System Cell Biology and Pathology.Frontiers in neuroanatomy · 2021Review
- Article
- Comprehensive Imaging of Sensory-Evoked Activity of Entire Neurons Within the Awake Developing Brain Using Ultrafast AOD-Based Random-Access Two-Photon Microscopy.Frontiers in neural circuits · 2020Article
- Label-free 3D-CLEM Using Endogenous Tissue Landmarks.iScience · 2018Article
- Experience-dependent structural plasticity targets dynamic filopodia in regulating dendrite maturation and synaptogenesis.Nature communications · 2018Article
- Article
- Design and implementation of multi-signal and time-varying neural reconstructions.Scientific data · 2018Article
- Coordinated Plasticity of Synapses and Astrocytes Underlies Practice-Driven Functional Vicariation in Peri-Infarct Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Quintuple labeling in the electron microscope with genetically encoded enhanced horseradish peroxidase.PloS one · 2018Article
- Imaging MyelinationBrain plasticity (Amsterdam, Netherlands) · 2016Review
- Mapping neurogenesis onset in the optic tectum of Xenopus laevis.Developmental neurobiology · 2016Article
- Experience-dependent plasticity of excitatory and inhibitory intertectal inputs in Xenopus tadpoles.Journal of neurophysiology · 2016Article
- Thyroid Hormone Acts Locally to Increase Neurogenesis, Neuronal Differentiation, and Dendritic Arbor Elaboration in the Tadpole Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Brain white matter structure and COMT gene are linked to second-language learning in adults.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Long-term stability of axonal boutons in the mouse barrel cortex.Developmental neurobiology · 2016Article
- On the Role of Glutamate in Presynaptic Development: Possible Contributions of Presynaptic NMDA Receptors.Biomolecules · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Dendrites, axons, and synapses are dynamic during circuit development; however, changes in microcircuit connections as branches stabilize have not been directly demonstrated. By combining in vivo time-lapse imaging of Xenopus tectal neurons with electron microscope reconstructions of imaged neurons, we report the distribution and ultrastructure of synapses on individual vertebrate neurons and relate these synaptic properties to dynamics in dendritic and axonal arbor structure over hours or days of imaging. Dynamic dendrites have a high density of immature synapses, whereas stable dendrites have sparser, mature synapses. Axons initiate contacts from multisynapse boutons on stable branches. Connections are refined by decreasing convergence from multiple inputs to postsynaptic dendrites and by decreasing divergence from multisynapse boutons to postsynaptic sites. Visual deprivation or NMDAR antagonists decreased synapse maturation and elimination, suggesting that coactive input activity promotes microcircuit development by concurrently regulating synapse elimination and maturation of remaining contacts.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.