ArticleHuman immunology2011
The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African Americans.
Article in Human immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.PLoS pathogens · 2012Trial
- Enterocyte Autoantibodies (GECAs) and HLA: Their Relationship with HIV Infection Pathogenesis.International journal of molecular sciences · 2026Review
- Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control.EBioMedicine · 2018Article
- Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection.Journal of virology · 2018Article
- Novel HLA class I associations with HIV-1 control in a unique genetically admixed population.Scientific reports · 2018Article
- Conserved HIV Epitopes for an Effective HIV Vaccine.Journal of clinical & cellular immunology · 2017Article
- Increased HIV-1 superinfection risk in carriers of specific human leukocyte antigen alleles.AIDS (London, England) · 2017Article
- Observational
- Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.PLoS pathogens · 2015Article
- CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: findings from an African cohort with prospective data.Frontiers in microbiology · 2015Article
- Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms.Journal of translational medicine · 2014Article
- Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions.Human genetics · 2014Article
- HIV subtype influences HLA-B*07:02-associated HIV disease outcome.AIDS research and human retroviruses · 2014Article
- Dynamics of viremia in primary HIV-1 infection in Africans: insights from analyses of host and viral correlates.Virology · 2014Article
- HLA-B*57 versus HLA-B*81 in HIV-1 infection: slow and steady wins the race?Journal of virology · 2013Article
- Cumulative impact of host and viral factors on HIV-1 viral-load control during early infection.Journal of virology · 2013Article
- Cell-Mediated Immunity in Elite Controllers Naturally Controlling HIV Viral Load.Frontiers in immunology · 2013Article
- Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.Journal of virology · 2012Article
- HIV-1 dynamics: a reappraisal of host and viral factors, as well as methodological issues.Viruses · 2012Review
- HIV and HLA class I: an evolving relationship.Immunity · 2012Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Populations of African ancestry continue to account for a disproportionate burden of the human immunodeficiency virus type 1 (HIV-1) epidemic in the United States. We investigated the effects of human leukocyte antigen (HLA) class I markers in association with virologic and immunologic control of HIV-1 infection among 338 HIV-1 subtype B-infected African Americans in 2 cohorts: Reaching for Excellence in Adolescent Care and Health (REACH) and HIV Epidemiology Research Study (HERS). One-year treatment-free interval measurements of HIV-1 RNA viral loads and CD4(+) T cells were examined both separately and combined to represent 3 categories of HIV-1 disease control (76 controllers, 169 intermediates, and 93 noncontrollers). Certain previously or newly implicated HLA class I alleles (A*32, A*36, A*74, B*14, B*1510, B*3501, B*45, B*53, B*57, Cw*04, Cw*08, Cw*12, and Cw*18) were associated with 1 or more of the endpoints in univariate analyses. After multivariable adjustments for other genetic and nongenetic risk factors of HIV-1 progression, the subset of alleles more strongly or consistently associated with HIV-1 disease control included A*32, A*74, B*14, B*45, B*53, B*57, and Cw*08. Carriage of infrequent HLA-B but not HLA-A alleles was associated with more favorable disease outcomes. Certain HLA class I associations with control of HIV-1 infection cross the boundaries of race and viral subtype, whereas others appear confined within one or the other of those boundaries.
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