ArticleMechanisms of ageing and development2011
Age trajectories of physiological indices in relation to healthy life course.
Article in Mechanisms of ageing and development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations.Mechanisms of ageing and developmentTrial
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- Article
- Clinical Challenges in Treating Cancer-Associated Thrombosis: A Clinically Oriented Review.Acta haematologica · 2025Review
- Usefulness of the cardiopulmonary exercise test up to the anaerobic threshold for pati-ents aged ≥ 80 years with cardiovascular disease on cardiac rehabilitation.Journal of rehabilitation medicine · 2024Observational
- The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms.Scientific reports · 2024Article
- Understanding Alzheimer's disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study.Mechanisms of ageing and development · 2023Article
- Diurnal dynamic range as index of dysregulation of system dynamics. A cortisol examplar using data from the Study of Midlife in the United States.Psychoneuroendocrinology · 2022Review
- Physiological Dysregulation, Frailty, and Impacts on Adverse Health and Functional Outcomes.Frontiers in medicine · 2021Article
- Multi-system physiological dysregulation and ageing in a subsistence population.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Functional aging in health and heart failure: the COmPLETE Study.BMC cardiovascular disorders · 2019Article
- "Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Examination of the Dimensions of Biological Age.Frontiers in genetics · 2019Review
- Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study.Experimental gerontology · 2018Article
- Men Sustain Higher Dysregulation Levels Than Women Without Becoming Frail.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Systems healthcare: a holistic paradigm for tomorrow.BMC systems biology · 2017Review
- Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging.Mechanisms of ageing and development · 2017Review
- PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study.Journal of hypertension · 2017Article
- stpm: an R package for stochastic process model.BMC bioinformatics · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We analysed relationship between the risk of onset of "unhealthy life" (defined as the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes in body mass index, diastolic blood pressure, hematocrit, pulse pressure, pulse rate, and serum cholesterol in the Framingham Heart Study (Original Cohort) using the stochastic process model of human mortality and aging. The analyses demonstrate how decline in resistance to stresses and adaptive capacity accompanying human aging can be evaluated from longitudinal data. We showed how these components of the aging process, as well as deviation of the trajectories of physiological indices from those minimising the risk at respective ages, can lead to an increase in the risk of onset of unhealthy life with age. The results indicate the presence of substantial gender difference in aging related decline in stress resistance and adaptive capacity, which can contribute to differences in the shape of the sex-specific patterns of incidence rates of aging related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.