ArticlePhysiology & behavior2011
"Snacking" causes long term attenuation of HPA axis stress responses and enhancement of brain FosB/deltaFosB expression in rats.
Article in Physiology & behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 66 citations in OpenAlex.
- Limited sucrose intake produces subregion-specific remodeling of perineuronal nets in the medial prefrontal cortex.Brain structure & function · 2026Article
- A larger amount of palatable food is needed to provide stress relief during Western diet-induced obesity.Physiology & behavior · 2026Article
- The impact of limited sucrose intake on perineuronal nets of parvalbumin interneurons in the basolateral amygdala: A potential role in stress resilience.Physiology & behavior · 2025Article
- Article
- Western diet-induced obesity interferes with the HPA axis-blunting effects of palatable food in male rats.Physiology & behavior · 2023Article
- Amygdala and nucleus accumbens activation during reward anticipation moderates the association between life stressor frequency and depressive symptoms.Journal of affective disorders · 2023Article
- Reward ameliorates depressive-like behaviors via inhibition of the substantia innominata to the lateral habenula projection.Science advances · 2022Article
- Limited cheese intake reduces HPA axis and behavioral stress responses in male rats.Physiology & behavior · 2021Article
- The influence of COVID-19-related stress on food motivation.Appetite · 2021Article
- Review
- Covid-19 and Mental Health: Could Visual Art Exposure Help?Frontiers in psychology · 2021Article
- Brain-gut-microbiome interactions in obesity and food addiction.Nature reviews. Gastroenterology & hepatology · 2020Review
- Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents.The international journal of neuropsychopharmacology · 2020Article
- Palatable food reduces anxiety-like behaviors and HPA axis responses to stress in female rats in an estrous-cycle specific manner.Hormones and behavior · 2019Article
- Reduced Sensory-Evoked Locus Coeruleus-Norepinephrine Neural Activity in Female Rats With a History of Dietary-Induced Binge Eating.Frontiers in psychology · 2019Article
- Palatable Food Affects HPA Axis Responsivity and Forebrain Neurocircuitry in an Estrous Cycle-specific Manner in Female Rats.Neuroscience · 2018Article
- Role of addiction and stress neurobiology on food intake and obesity.Biological psychology · 2018Review
- Sucrose-induced plasticity in the basolateral amygdala in a 'comfort' feeding paradigm.Brain structure & function · 2017Article
- Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge-like palatable food consumption in female rats.The International journal of eating disorders · 2017Article
- HPA Axis Interactions with Behavioral Systems.Comprehensive Physiology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A history of limited, intermittent intake of palatable food (sucrose drink) attenuates hypothalamic-pituitary-adrenal (HPA) axis stress responses and induces markers of neuronal plasticity in stress- and reward-regulatory brain regions. Synaptic plasticity could provide a mechanism for long-term changes in neuronal function, implying that sucrose stress-dampening may endure over long periods of time. The present study tests the persistence of HPA axis dampening and plasticity after cessation of palatable drinking. Adult, male Long-Evans rats (n=10-13) with free access to water and chow were given additional twice-daily access to 4ml sucrose (30%) or water for 14days. Rats were subsequently tested for HPA responsiveness to an acute (20min) restraint stress at 1, 6 and 21days after the cessation of sucrose. Brains were collected for immunohistochemical analysis of FosB/deltaFosB, a marker of long-term neuronal plasticity, in the basolateral amygdala (BLA) and nucleus accumbens (NuAc). Prior sucrose consumption significantly decreased the plasma corticosterone response to restraint at 1day after the last palatable drink presentation, and also increased FosB/deltaFosB-positive cells in the BLA and in the NuAc core. This HPA-dampening persisted through 21days after the termination of the palatable drink, as did the increased FosB/deltaFosB immunoreactivity in both the BLA and the NuAc core. These data suggest that chronic palatable food intake causes lasting changes in stress/reward-modulatory circuitry and that the suppressed hormonal response to stress that can persist well beyond periods of palatable drink exposure.
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