ArticleRespiratory research2011
Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study.
Article in Respiratory research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 85 citations in OpenAlex.
- mApplied biochemistry and biotechnology · 2026Article
- Tobacco and asthma: presenting the world health organization (WHO) tobacco knowledge summary.Substance abuse treatment, prevention, and policy · 2025Review
- Impact of smoking behaviors on asthma incidence and allcause mortality in middle-aged and older adults: A longitudinal study from China.Tobacco induced diseases · 2025Article
- Interplay of IL-33 and IL-35 Modulates Th2/Th17 Responses in Cigarette Smoke Exposure HDM-Induced Asthma.Inflammation · 2024Article
- Risk factors of allergic rhinitis and its prevention strategies.Frontiers in allergy · 2024Review
- Different clinical characteristics of current smokers and former smokers with asthma: a cross-sectional study of adult asthma patients in China.Scientific reports · 2023Article
- Documentation of smoking in scheduled asthma contacts in primary health care: a 12-year follow-up study.NPJ primary care respiratory medicine · 2022Article
- The Impact of Tobacco Cigarettes, Vaping Products and Tobacco Heating Products on Oxidative Stress.Antioxidants (Basel, Switzerland) · 2022Review
- Asthma Prevalence and its Risk Factors Among a Multi-Ethnic Adult Population.The Yale journal of biology and medicine · 2021Article
- Asthma and COVID-19: a dangerous liaison?Asthma research and practice · 2021Review
- The Impact of Tobacco Smoking on Adult Asthma Outcomes.International journal of environmental research and public health · 2021Article
- Phenotype-Guided Asthma Therapy: An Alternative Approach to Guidelines.Journal of asthma and allergy · 2021Review
- Impact of Air Pollution on Asthma Outcomes.International journal of environmental research and public health · 2020Review
- What clinical and health psychology tell to internists and emergency physicians about harm reduction, addiction and asthma?Internal and emergency medicine · 2020Article
- Symptom control among asthmatics with a clinically significant smoking history: a cross-sectional study in Finland.BMC pulmonary medicine · 2020Article
- A Proposed Approach to Chronic Airway Disease (CAD) Using Therapeutic Goals and Treatable Traits: A Look to the Future.International journal of chronic obstructive pulmonary disease · 2020Article
- Critical role of interleukin-23 in development of asthma promoted by cigarette smoke.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Increased Risk of Exacerbation in Asthma Predominant Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome.Tuberculosis and respiratory diseases · 2018Article
- Modelling the asthma phenotype: impact of cigarette smoke exposure.Respiratory research · 2018Article
- Treatment of Allergic Rhinitis as a Strategy for Preventing Asthma.Current allergy and asthma reports · 2018Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma.
methodsAllergic rhinitis subjects with no asthma (n = 371) were followed-up for 10 years and routinely examined for asthma diagnosis. In those who developed asthma (n = 152), clinical severity and levels of asthma control were determined. Among these subjects, 74 (48.7%) were current smokers, 17 (11.2%) former smokers, and 61 (40.1%) never smokers.
resultsWhen comparing current or past smokers to never smokers they had a higher risk of severe asthma in the univariate analysis, which became non-significant in the multivariate analysis. On the other hand, the categories of pack-years were significantly related to severe asthma in a dose response relationship in both the univariate and multivariate analysis: compared to 0 pack years, those who smoked 1-10 pack-years had an OR(95% CI) of 1.47(0.46-4.68), those who smoked 11-20 pack-years had an OR of 2.85(1.09-7.46) and those who smoked more than 20 pack-years had an OR of 5.59(1.44-21.67) to develop more severe asthma. Smokers with asthma were also more likely to have uncontrolled disease. A significant dose-response relationship was observed for pack-years and uncontrolled asthma. Compared to 0 pack years, those who smoked 1-10 pack-years had an OR of 5.51(1.73-17.54) and those who smoked more than 10 pack-years had an OR of 13.38(4.57-39.19) to have uncontrolled asthma.
conclusionsThe current findings support the hypothesis that cigarette smoking is an important predictor of asthma severity and poor asthma control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.