ReviewMicrobial biotechnology2008
Microcalorimetry: a response to challenges in modern biotechnology.
Review in Microbial biotechnology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Isothermal Titration Calorimetry for Investigating Thermodynamics of Protein-Lipid Interactions.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Thermotolerant class A acid phosphatase active across broad pH range and diverse substrates.Protein science : a publication of the Protein Society · 2025Article
- Transforming Agricultural and Sulfur Waste into Fertilizer: Assessing the Short-Term Effects on Microbial Biodiversity via a Metagenomic Approach.Life (Basel, Switzerland) · 2024Article
- Characterization of an extremophile bacterial acid phosphatase derived from metagenomics analysis.Microbial biotechnology · 2024Article
- Macromolecular interactions in vitro, comparing classical and novel approaches.European biophysics journal : EBJ · 2021Article
- Functional Annotation of Bacterial Signal Transduction Systems: Progress and Challenges.International journal of molecular sciences · 2018Review
- The activity of the C4-dicarboxylic acid chemoreceptor of Pseudomonas aeruginosa is controlled by chemoattractants and antagonists.Scientific reports · 2018Article
- Toxic effect of two kinds of mineral collectors on soil microbial richness and activity: analysis by microcalorimetry, microbial count, and enzyme activity assay.Environmental science and pollution research international · 2017Article
- Paralogous Regulators ArsR1 and ArsR2 of Pseudomonas putida KT2440 as a Basis for Arsenic Biosensor Development.Applied and environmental microbiology · 2016Article
- Effect of three typical sulfide mineral flotation collectors on soil microbial activity.Environmental science and pollution research international · 2016Article
- Insights into Protein-Ligand Interactions: Mechanisms, Models, and Methods.International journal of molecular sciences · 2016Review
- Identification of a Chemoreceptor inFrontiers in microbiology · 2016Article
- Study of rabies virus by Differential Scanning Calorimetry.Biochemistry and biophysics reports · 2015Article
- Identification of a Chemoreceptor for C2 and C3 Carboxylic Acids.Applied and environmental microbiology · 2015Article
- Multiple signals modulate the activity of the complex sensor kinase TodS.Microbial biotechnology · 2015Article
- GtrS and GltR form a two-component system: the central role of 2-ketogluconate in the expression of exotoxin A and glucose catabolic enzymes in Pseudomonas aeruginosa.Nucleic acids research · 2014Article
- Identification of new residues involved in intramolecular signal transmission in a prokaryotic transcriptional repressor.Journal of bacteriology · 2014Article
- Transcriptional control by two interacting regulatory proteins: identification of the PtxS binding site at PtxR.Nucleic acids research · 2013Article
- High specificity in CheR methyltransferase function: CheR2 of Pseudomonas putida is essential for chemotaxis, whereas CheR1 is involved in biofilm formation.The Journal of biological chemistry · 2013Article
- Study of the TmoS/TmoT two-component system: towards the functional characterization of the family of TodS/TodT like systems.Microbial biotechnology · 2012Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Almost any process in life is accompanied by heat changes which can be monitored by isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC). Both techniques are now established tools in fundamental research but over the last decade a clear tendency towards more problem-driven applications is noted. This review aims at summarizing these problem-oriented applications of microcalorimetry and the solutions both techniques can provide to problems in biotechnology. The biotechnological issues to which microcalorimetry has been successfully applied are as diverse as rational drug design, overcoming drug resistance, optimization of long-term stability of proteins, estimation of the bioavailability of drugs, control of complex pharmaceutical products or the optimization of gene delivery efficiency. The main limitation of microcalorimetry, which is the relatively large amounts of sample necessary for analysis, is less important in the biotechnology sector which frequently uses large-scale produced bulk products for analysis. The recently developed high-throughput DSC and ITC microcalorimeters will additionally reduce the labour intensity of these techniques. Due to the precision of microcalorimetric analyses and the versatility of processes which can be studied, it is expected that ITC and DSC will soon be key technologies in biotechnological research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.