ArticleMicrobial biotechnology2008
Pseudomonas aeruginosa PAO1 virulence factors and poplar tree response in the rhizosphere.
Article in Microbial biotechnology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 76 citations in OpenAlex.
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- Introduce a novel post-biotic against Pseudomonas aeruginosa biofilm formation using Escherchia coli Nissle1917 outer membrane vesicles.BMC research notes · 2023Article
- The ColR/S two-component system is a conserved determinant of host association across Pseudomonas species.The ISME journal · 2023Article
- Combination drug strategies for biofilm eradication using synthetic and natural agents in KAPE pathogens.Frontiers in cellular and infection microbiology · 2023Review
- Flavonoids Are Intra- and Inter-Kingdom Modulator Signals.Microorganisms · 2022Review
- Condensins are essential for Pseudomonas aeruginosa corneal virulence through their control of lifestyle and virulence programs.Molecular microbiology · 2022Article
- A Berberine Bridge Enzyme-Like Protein,Frontiers in plant science · 2022Article
- The secret lives of single cells.Microbial biotechnology · 2022Article
- Bacteria associated with vascular wilt of poplar.Archives of microbiology · 2021Article
- Predicting drug targets by homology modelling of Pseudomonas aeruginosa proteins of unknown function.PloS one · 2021Article
- Survival strategy of Pseudomonas aeruginosa on the nanopillar topography of dragonfly (Pantala flavescens) wing.AMB Express · 2020Article
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- Volatile compounds from beneficial or pathogenic bacteria differentially regulate root exudation, transcription of iron transporters, and defense signaling pathways in Sorghum bicolor.Plant molecular biology · 2018Article
- The activity of the C4-dicarboxylic acid chemoreceptor of Pseudomonas aeruginosa is controlled by chemoattractants and antagonists.Scientific reports · 2018Article
- Flavonoids SuppressThe Journal of biological chemistry · 2017Article
- YeATSAM analysis of the walnut and chickpea transcriptome reveals key genes undetected by current annotation tools.F1000Research · 2016Article
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- Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae.PloS one · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Whole-transcriptome analysis was used here for the first time in the rhizosphere to discern the genes involved in the pathogenic response of Pseudomonas aeruginosa PAO1 as well as to discern the response of the poplar tree. Differential gene expression shows that 185 genes of the bacterium and 753 genes of the poplar tree were induced in the rhizosphere. Using the P. aeruginosa transcriptome analysis, isogenic knockout mutants, and two novel plant assays (poplar and barley), seven novel PAO1 virulence genes were identified (PA1385, PA2146, PA2462, PA2463, PA2663, PA4150 and PA4295). The uncharacterized putative haemolysin repressor, PA2463, upon inactivation, resulted in greater poplar virulence and elevated haemolysis while this mutant remained competitive in the rhizosphere. In addition, disruption of the haemolysin gene itself (PA2462) reduced the haemolytic activity of P. aeruginosa, caused less cytotoxicity and reduced barley virulence, as expected. Inactivating PA1385, a putative glycosyl transferase, reduced both poplar and barley virulence. Furthermore, disrupting PA2663, a putative membrane protein, reduced biofilm formation by 20-fold. Inactivation of PA3476 (rhlI) increased virulence with barley as well as haemolytic activity and cytotoxicity, so quorum sensing is important in plant pathogenesis. Hence, this strategy is capable of elucidating virulence genes for an important pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.