ArticlePhotochemistry and photobiology
Analysis of the bacterial heat shock response to photodynamic therapy-mediated oxidative stress.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Illuminating the mechanism: gene expression responses to antimicrobial photodynamic therapy.BMC genomics · 2026Review
- Beyond Resistance: Tolerance and Resilience of Bacteria to Photodynamic and Oxidative Stress.International journal of molecular sciences · 2025Review
- Heat Shock Protein Inhibitors Show Synergistic Antibacterial Effects with Photodynamic Therapy on Caries-Related StreptococcimSphere · 2023Article
- Gram-negative quorum sensing signalling enhances biofilm formation and virulence traits in gram-positive pathogenJournal of oral microbiology · 2023Article
- Exploiting Violet-Blue Light to KillmSystems · 2022Article
- Inactivation ofMicroorganisms · 2022Article
- Sub-lethal antimicrobial photodynamic inactivation: an in vitro study on quorum sensing-controlled gene expression of Pseudomonas aeruginosa biofilm formation.Lasers in medical science · 2019Article
- The effect of antimicrobial photodynamic therapy against virulence genes expression in colistin-resistanceLaser therapy · 2019Article
- Selective Photoinduced Antibacterial Activity of Amoxicillin-Coated Gold Nanoparticles: From One-Step Synthesis to in Vivo Cytocompatibility.ACS omega · 2018Article
- Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation?Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2017Review
- Assessment of the potential for resistance to antimicrobial violet-blue light inAntimicrobial resistance and infection control · 2017Article
- Streptococcus mutans photoinactivation by combination of short exposure of a broad-spectrum visible light and low concentrations of photosensitizers.Photomedicine and laser surgery · 2014Article
- Photodynamic and antibiotic therapy impair the pathogenesis of Enterococcus faecium in a whole animal insect model.PloS one · 2013Article
- Article
- Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform.Frontiers in microbiology · 2012Article
- Bacteriophytochrome controls carotenoid-independent response to photodynamic stress in a non-photosynthetic rhizobacterium, Azospirillum brasilense Sp7.Scientific reports · 2012Article
- Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Antimicrobial photodynamic therapy (PDT) has recently emerged as an effective modality for the selective destruction of bacteria and other pathogenic microorganisms. We investigated whether PDT induced protective responses such as heat shock proteins (HSPs) in bacteria. Using the photosensitizer Toluidine Blue O (TBO) at sublethal PDT conditions, a seven-fold increase in bacterial HSP GroEL and a three-fold increase in HSP DnaK were observed in Escherichia coli post PDT. Pretreatment with 50°C heat for 30 min reduced PDT killing in both E. coli and in Enterococcus faecalis, with the most pronounced inhibition occurring at 50 μm TBO with 5 J cm(-2) 635 nm light, where E. coli killing was reduced by 2 log(10) and E. faecalis killing was reduced by 4 log(10). Finally, inhibition of the highly conserved chaperone DnaK using a small molecule benzylidene lactam HSP inhibitor potentiated (but not significantly) the effect of PDT at a TBO concentration of 2.5 μm in E. faecalis; however, this effect was not observed in E. coli presumably because inhibitor could not gain access due to Gram-negative permeability barrier. Induction of HSPs may be a mechanism whereby bacteria could become resistant to PDT and warrants the need for further study in the application of dual PDT-HSP-inhibition therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.