ArticleAnalytical chemistry2011
Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed.
- From single cell analysis to 3D micro physiological systems: microfluidic tools integrating cancer cell targets for delineating natural killer cell biology.Microsystems & nanoengineering · 2026Review
- Modeling glioblastoma relapse in vitro: a critical journey from 2D models to organ-on-chip alternatives.NPJ precision oncology · 2026Review
- Multiplexed detection of respiratory virus RNA using optical pH sensors and injection-molded centrifugal microfluidics.Mikrochimica acta · 2025Article
- Transformation gap from research findings to large-scale commercialized products in microfluidic field.Materials today. Bio · 2024Review
- Rapid prototyping of thermoplastic microfluidic devices via SLA 3D printing.Scientific reports · 2024Article
- Universal and Versatile Magnetic Connectors for Microfluidic Devices.Micromachines · 2024Article
- Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip.World journal of stem cells · 2023Article
- Fungi-on-a-Chip: microfluidic platforms for single-cell studies on fungi.FEMS microbiology reviews · 2022Review
- The Fabrication and Bonding of Thermoplastic Microfluidics: A Review.Materials (Basel, Switzerland) · 2022Review
- Bonding Strategies for Thermoplastics Applicable for Bioanalysis and Diagnostics.Micromachines · 2022Review
- The impact of microfluidics in high-throughput drug-screening applications.Biomicrofluidics · 2022Review
- Customizable Microfluidic Origami Liver-on-a-Chip (oLOC).Advanced materials technologies · 2022Article
- Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene.Micromachines · 2021Article
- Flexible Enzymatic Glucose Electrochemical Sensor Based on Polystyrene-Gold Electrodes.Micromachines · 2021Article
- The Current Challenges for Drug Discovery in CNS Remyelination.International journal of molecular sciences · 2021Review
- A Facile Approach for Rapid Prototyping of Microneedle Molds, Microwells and Micro-Through-Holes in Various Substrate Materials Using COBiomedicines · 2020Article
- Rapid Fabrication of Membrane-Integrated Thermoplastic Elastomer Microfluidic Devices.Micromachines · 2020Article
- Application of Microfluidic Chip Technology in Food Safety Sensing.Sensors (Basel, Switzerland) · 2020Review
- Injection molded open microfluidic well plate inserts for user-friendly coculture and microscopy.Lab on a chip · 2020Article
- Microfluidic tools for lipid production and modification: a review.Environmental science and pollution research international · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Microfluidic cell-based systems have enabled the study of cellular phenomena with improved spatiotemporal control of the microenvironment and at increased throughput. While poly(dimethylsiloxane) (PDMS) has emerged as the most popular material in microfluidics research, it has specific limitations that prevent microfluidic platforms from achieving their full potential. We present here a complete process, ranging from mold design to embossing and bonding, that describes the fabrication of polystyrene (PS) microfluidic devices with similar cost and time expenditures as PDMS-based devices. Emphasis was placed on creating methods that can compete with PDMS fabrication methods in terms of robustness, complexity, and time requirements. To achieve this goal, several improvements were made to remove critical bottlenecks in existing PS embossing methods. First, traditional lithographic techniques were adapted to fabricate bulk epoxy molds capable of resisting high temperatures and pressures. Second, a method was developed to emboss through-holes in a PS layer, enabling creation of large arrays of independent microfluidic systems on a single device without need to manually create access ports. Third, thermal bonding of PS layers was optimized in order to achieve quality bonding over large arrays of microsystems. The choice of materials and methods was validated for biological function in two different cell-based applications to demonstrate the versatility of our streamlined fabrication process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.