Evidence map›Paper›PMID 21259449›Full record

ArticlePediatric pulmonology2011

Screening for symptoms of depression and anxiety in adolescents and young adults with cystic fibrosis.

Avani C Modi, Kimberly A Driscoll, Karen Montag-Leifling, James D Acton

Abstract read
In one paragraph

Article in Pediatric pulmonology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. The patient's experience of primary ciliary dyskinesia: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017
    Pooled it
  3. Pooled it
  4. Depression and anxiety in adolescents with cystic fibrosis in Brazil: prevalence, stability over time, and relationship with treatment adherence.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025
    Observational
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  11. Psychologists and the Transition From Pediatrics to Adult Health Care.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2015
    Article
  12. Article
  13. Long-term follow-up of cystic fibrosis newborn screening: psychosocial functioning of adolescents and young adults.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2014
    Article
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Avani C ModiCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA. avani.modi@cchmc.org
Kimberly A Driscoll
Karen Montag-Leifling
James D Acton

Funding

Research Training in Child Behavior and NutritionT32DK063929 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI SCOTT W POWERS, MARGARET H ZELLER · 2003 to 2026
$6.0M
NIDDK NIH HHS L40 DK076474NIDDK NIH HHS T32 DK063929NIDDK NIH HHS T32DK063929
6 · The paper itself

Abstract

backgroundAlthough studies have assessed symptoms of depression and anxiety in individuals with cystic fibrosis (CF), few have been conducted since the advent of new medical treatments (e.g., nebulized antibiotics, ThAIRpy Vest). Study objectives were to: (1) document symptoms of depression and anxiety for adolescents and young adults with CF and compare with normative values, (2) examine the associations among depressive/anxiety symptoms and gender, age, lung function, and body mass index, and (3) determine the relations between adolescent and caregiver symptoms of depression and anxiety.

methodsPatients and caregivers completed the Hospital Anxiety and Depression Scale (HADS) anytime (e.g., beginning or end) during routine CF clinic appointments.

resultsParticipants included 59 adolescents/young adults with CF (M(age)  = 15.8 years, 54% female, 98% Caucasian, M(FEV1% predicted)  = 84.6) and caregivers of 40 adolescents. Although symptom scores were in the normative range for patients with CF (M(Depression)  = 2.27 and M(Anxiety)  = 5.59), 3% and 32% exhibited clinically elevated symptoms of depression and anxiety, respectively. Symptoms of depression and anxiety were significantly associated with age (r = 0.28, 0.36). Symptoms of depression and anxiety were also positively correlated (r = 0.48). Females endorsed higher anxiety symptoms than males. While adolescent and caregiver anxiety scores were not related, higher caregiver depressive symptoms were associated with older patient age and worse lung function.

conclusionsData from the current study suggest low levels of depressive symptoms and substantial levels of anxiety symptoms in adolescents and young adults with CF. Consistent with prior literature, depressive symptoms appear higher in older patients and are significantly associated with anxiety symptoms. Caregiver symptomology appears to be more affected by an adolescent's health status, suggesting a need to screen caregivers when health begins to decline.

Indexed as

AdolescentAdultAnxietyCaregiversCystic FibrosisDepressionFemaleHumansMaleMass ScreeningPrevalenceRespiratory Function TestsYoung Adult

Identifiers

PMID21259449
PMCPMC3462584

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.