ReviewCerebellum (London, England)2011
Mini-review: synaptic integration in the cerebellar nuclei--perspectives from dynamic clamp and computer simulation studies.
Review in Cerebellum (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Biophysical KeLife · 2022Article
- Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs.PLoS computational biology · 2021Article
- Cerebellar Cortex 4-12 Hz Oscillations and Unit Phase Relation in the Awake Rat.Frontiers in systems neuroscience · 2020Article
- Article
- Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments.Scientific reports · 2016Article
- Whole-Cell Properties of Cerebellar Nuclei Neurons In Vivo.PloS one · 2016Article
- Stochastic Synchronization in Purkinje Cells with Feedforward Inhibition Could Be Studied with Equivalent Phase-Response Curves.Journal of mathematical neuroscience · 2015Article
- Flocculus Purkinje cell signals in mouse Cacna1a calcium channel mutants of escalating severity: an investigation of the role of firing irregularity in ataxia.Journal of neurophysiology · 2014Article
- Bidirectional modulation of deep cerebellar nuclear cells revealed by optogenetic manipulation of inhibitory inputs from Purkinje cells.Neuroscience · 2014Article
- A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Gain control of synaptic response function in cerebellar nuclear neurons by a calcium-activated potassium conductance.Cerebellum (London, England) · 2013Article
- The cerebellar nuclei take center stage.Cerebellum (London, England) · 2011Article
- The mysterious microcircuitry of the cerebellar nuclei.The Journal of physiology · 2011Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The cerebellar nuclei (CN) process inhibition from Purkinje cells (PC) and excitation from mossy and climbing fiber collaterals. CN neurons in slices show intrinsic pacemaking activity, which is easily modulated by synaptic inputs. Our work using dynamic clamping and computer modeling shows that synchronicity between PC inputs is an important factor in determining spike rate and spike timing of CN neurons and that brief pauses in PC inputs provide a potent stimulus to trigger CN spikes. Excitatory input can equally control spike rate, but, due to a large slow, NMDA component also amplifies responses to inhibitory inputs. Intrinsic properties of CN neurons are well suited to provide prolonged responses to strong input transients and could be involved in motor pattern generation. One such specific mechanism is given by fast and slow rebound bursting. Nevertheless, we are just beginning to unravel synaptic integration in the CN, and the outcome of the work to date is best characterized by the generation of new specific questions that lend themselves to a combined experimental and computer modeling approach in future studies.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.