ArticleFrontiers in integrative neuroscience2010
Functional roles of distributed synaptic clusters in the mitral-granule cell network of the olfactory bulb.
Article in Frontiers in integrative neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Changes in pairwise correlations during running reshape global network state in the main olfactory bulb.Journal of neurophysiology · 2021Article
- An Evolutionary Microcircuit Approach to the Neural Basis of High Dimensional Sensory Processing in Olfaction.Frontiers in cellular neuroscience · 2021Article
- Predicting brain organization with a computational model: 50-year perspective on lateral inhibition and oscillatory gating by dendrodendritic synapses.Journal of neurophysiology · 2020Review
- Parallel odor processing by mitral and middle tufted cells in the olfactory bulb.Scientific reports · 2018Article
- Synaptic E-I Balance Underlies Efficient Neural Coding.Frontiers in neuroscience · 2018Review
- Dense encoding of natural odorants by ensembles of sparsely activated neurons in the olfactory bulb.Scientific reports · 2016Article
- Control of Mitral/Tufted Cell Output by Selective Inhibition among Olfactory Bulb Glomeruli.Neuron · 2016Article
- Biophysical constraints on lateral inhibition in the olfactory bulb.Journal of neurophysiology · 2016Article
- Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb.Frontiers in computational neuroscience · 2016Article
- Odor Experience Facilitates Sparse Representations of New Odors in a Large-Scale Olfactory Bulb Model.Frontiers in neuroanatomy · 2016Article
- Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer.The Journal of comparative neurology · 2015Article
- Bulbar microcircuit model predicts connectivity and roles of interneurons in odor coding.PloS one · 2015Article
- Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.Frontiers in computational neuroscience · 2014Article
- A spiking neural network model of self-organized pattern recognition in the early mammalian olfactory system.Frontiers in neural circuits · 2014Article
- Using Strahler's analysis to reduce up to 200-fold the run time of realistic neuron models.Scientific reports · 2013Article
- Sparse distributed representation of odors in a large-scale olfactory bulb circuit.PLoS computational biology · 2013Article
- Burst firing versus synchrony in a gap junction connected olfactory bulb mitral cell network model.Frontiers in computational neuroscience · 2012Article
- Mitral cell spike synchrony modulated by dendrodendritic synapse location.Frontiers in computational neuroscience · 2012Article
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4 authors.
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Abstract
Odors are encoded in spatio-temporal patterns within the olfactory bulb, but the mechanisms of odor recognition and discrimination are poorly understood. It is reasonable to postulate that the olfactory code is sculpted by lateral and feedforward inhibition mediated by granule cells onto the mitral cells. Recent viral tracing and physiological studies revealed patterns of distributed granule cell synaptic clusters that provided additional clues to the possible mechanisms at the network level. The emerging properties and functional roles of these patterns, however, are unknown. Here, using a realistic model of 5 mitral and 100 granule cells we show how their synaptic network can dynamically self-organize and interact through an activity-dependent dendrodendritic mechanism. The results suggest that the patterns of distributed mitral-granule cell connectivity may represent the most recent history of odor inputs, and may contribute to the basic processes underlying mixture perception and odor qualities. The model predicts how and why the dynamical interactions between the active mitral cells through the granule cell synaptic clusters can account for a variety of puzzling behavioral results on odor mixtures and on the emergence of synthetic or analytic perception.
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