Evidence map›Paper›PMID 21258541›Full record

ArticleBiomedical optics express2010

Depth-resolved measurement of mucosal microvascular blood content using 
low-coherence enhanced backscattering spectroscopy.

Andrew J Radosevich, Vladimir M Turzhitsky, Nikhil N Mutyal, Jeremy D Rogers, Valentina Stoyneva, Ashish Kumar Tiwari, Mart De La Cruz, Dhananjay P Kunte, Ramesh K Wali, Hemant K Roy and 1 more

Abstract read
In one paragraph

Article in Biomedical optics express, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Polarized Enhanced Backscattering Spectroscopy for Characterization of Biological Tissues at Subdiffusion Length-scales.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society · 2012
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Andrew J Radosevich
Vladimir M Turzhitsky
Nikhil N Mutyal
Jeremy D Rogers
Valentina Stoyneva
Ashish Kumar Tiwari
Mart De La Cruz
Dhananjay P Kunte
Ramesh K Wali
Hemant K Roy
Vadim Backman
Northwestern University · USNorthShore University HealthSystem · US

Funding

Novel Biophotonics Methodology for Colon Cancer ScreeningR01CA128641 · NCI · NORTHWESTERN UNIVERSITY · PI BACKMAN, VADIM · 2008 to 2012
$7.3M
Mechanisms of Light Scattering in Living TissuesR01EB003682 · NIBIB · NORTHWESTERN UNIVERSITY · PI BACKMAN, VADIM, PRADHAN, PRABHAKAR · 2005 to 2013
$2.2M
Spectroscopy of blood supply changes in early precancerR01CA109861 · NCI · NORTHWESTERN UNIVERSITY · PI BACKMAN, VADIM · 2005 to 2013
$1.7M
Optically Monitoring Colon Microcirculation in PrecancerR01CA118794 · NCI · NORTHWESTERN UNIVERSITY · PI BACKMAN, VADIM · 2007 to 2009
$786k
NCI NIH HHS R01 CA109861NCI NIH HHS R01 CA118794NCI NIH HHS R01 CA128641NIBIB NIH HHS R01 EB003682
6 · The paper itself

Abstract

Low-coherence enhanced backscattering (LEBS) spectroscopy is a light scattering technique which uses partial spatial coherence broadband illumination to interrogate the optical properties at sub-diffusion length scales. In this work, we present a post-processing technique which isolates the hemoglobin concentration at different depths within a sample using a single spectroscopic LEBS measurement with a fixed spatial coherence of illumination. We verify the method with scattering (spectralon reflectance standard and polystyrene microspheres) and absorbing (hemoglobin) phantoms. We then demonstrate the relevance of this method for quantifying hemoglobin content as a function of depth within biological tissue using the azoxymethane treated animal model of colorectal cancer.

Identifiers

PMID21258541
PMCPMC3018078
OpenAlexW1974335363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.