ArticleBiomedical optics express2010
Detection of doxorubicin-induced apoptosis of leukemic T-lymphocytes by laser tweezers Raman spectroscopy.
Article in Biomedical optics express, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Spectroscopic Signature of Apoptosis Induced by Venetoclax in Philadelphia-Positive Acute Lymphoblastic Leukemia.Analytical chemistry · 2026Article
- Determination of Raman spectrum under different culture conditions: preliminary research on bacterial fish pathogens.Animal biotechnology · 2024Article
- Alveoli-Like Multifunctional Scaffolds for Optical and Electrochemical In Situ Monitoring of Cellular Responses from Type II Pneumocytes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Study on the chemodrug-induced effect in nasopharyngeal carcinoma cells using laser tweezer Raman spectroscopy.Biomedical optics express · 2020Article
- New perspectives for viability studies with high-content analysis Raman spectroscopy (HCA-RS).Scientific reports · 2019Article
- Anti-cancer effect of bee venom on human MDA-MB-231 breast cancer cells using Raman spectroscopy.Biomedical optics express · 2018Article
- Raman Spectroscopy of Optically Trapped Single Biological Micro-Particles.Sensors (Basel, Switzerland) · 2015Review
- Cell death stages in single apoptotic and necrotic cells monitored by Raman microspectroscopy.Scientific reports · 2014Article
- Engineered tumor cell apoptosis monitoring method based on dynamic laser tweezers.BioMed research international · 2014Article
- Raman spectroscopy in biomedicine - non-invasive in vitro analysis of cells and extracellular matrix components in tissues.Biotechnology journal · 2013Review
- A simple and rapid detection of tissue adhesive-induced biochemical changes in cells and DNA using Raman spectroscopy.Biomedical optics express · 2013Article
- Biocompatibility of a novel cyanoacrylate based tissue adhesive: cytotoxicity and biochemical property evaluation.PloS one · 2013Article
- A study of Docetaxel-induced effects in MCF-7 cells by means of Raman microspectroscopy.Analytical and bioanalytical chemistry · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laser tweezers Raman spectroscopy (LTRS) was used to acquire the Raman spectra of leukemic T lymphocytes exposed to the chemotherapy drug doxorubicin at different time points over 72 hours. Changes observed in the Raman spectra were dependent on drug exposure time and concentration. The sequence of spectral changes includes an intensity increase in lipid Raman peaks, followed by an intensity increase in DNA Raman peaks, and finally changes in DNA and protein (phenylalanine) Raman vibrations. These Raman signatures are consistent with vesicle formation, cell membrane blebbing, chromatin condensation, and the cytoplasm of dead cells during the different stages of drug-induced apoptosis. These results suggest the potential of LTRS as a real-time single cell tool for monitoring apoptosis, evaluating the efficacy of chemotherapeutic treatments, or pharmaceutical testing.
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Registered trials
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