ArticleBiomedical optics express2010
Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy.
Article in Biomedical optics express, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- AI-driven digital holographic microscopy for label-free quantitative cellular analysis: toward low-cost and field-deployable platforms.Biomedical optics express · 2026Review
- Automated fast label-free quantification of cardiomyocyte dynamics with raw holograms for cardiotoxicity screening.Biomedical optics express · 2025Article
- Label-free quantitative measurement of cardiovascular dynamics in a zebrafish embryo using frequency-comb-referenced-quantitative phase imaging.Journal of biomedical optics · 2021Article
- Digital holographic microscopy evaluation of dynamic cell response to electroporation.Biomedical optics express · 2021Article
- 3D imaging using scanning diffractometry.Scientific reports · 2021Article
- Tissue dynamics spectroscopic imaging: functional imaging of heterogeneous cancer tissue.Journal of biomedical optics · 2020Article
- Automated single cardiomyocyte characterization by nucleus extraction from dynamic holographic images using a fully convolutional neural network.Biomedical optics express · 2020Article
- Diffraction-based technology for the monitoring of contraction dynamics in 3D and 2D tissue models.Biomedical optics express · 2020Article
- High-resolution 3D refractive index microscopy of multiple-scattering samples from intensity images.Optica · 2019Article
- Shear Modulus Measurement by Quantitative Phase Imaging and Correlation with Atomic Force Microscopy.Biophysical journal · 2019Article
- Surface plasmon resonance imaging of excitable cells.Journal of physics D: Applied physics · 2019Article
- Automated quantification study of human cardiomyocyte synchronization using holographic imaging.Biomedical optics express · 2019Article
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- Wavefront division digital holographic microscopy.Biomedical optics express · 2018Article
- Reflective lens-free imaging on high-density silicon microelectrode arrays for monitoring and evaluation ofBiomedical optics express · 2018Article
- Widefield standing wave microscopy of red blood cell membrane morphology with high temporal resolution.Biomedical optics express · 2018Article
- Cellular shear stiffness reflects progression of arsenic-induced transformation during G1.Carcinogenesis · 2018Article
- Structured illumination microscopy for dual-modality 3D sub-diffraction resolution fluorescence and refractive-index reconstruction.Biomedical optics express · 2017Article
- Optophysiology of cardiomyocytes: characterizing cellular motion with quantitative phase imaging.Biomedical optics express · 2017Article
- Automated red blood cells extraction from holographic images using fully convolutional neural networks.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We apply wide-field interferometric microscopy techniques to acquire quantitative phase profiles of ventricular cardiomyocytes in vitro during their rapid contraction with high temporal and spatial resolution. The whole-cell phase profiles are analyzed to yield valuable quantitative parameters characterizing the cell dynamics, without the need to decouple thickness from refractive index differences. Our experimental results verify that these new parameters can be used with wide field interferometric microscopy to discriminate the modulation of cardiomyocyte contraction dynamics due to temperature variation. To demonstrate the necessity of the proposed numerical analysis for cardiomyocytes, we present confocal dual-fluorescence-channel microscopy results which show that the rapid motion of the cell organelles during contraction preclude assuming a homogenous refractive index over the entire cell contents, or using multiple-exposure or scanning microscopy.
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Registered trials
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