ReviewHormones & cancer2010
Challenges and pitfalls in the management of parathyroid carcinoma: 17-year follow-up of a case and review of the literature.
Review in Hormones & cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Microwave ablation permits an effective and safe treatment for lung metastasis of parathyroid carcinoma: A Retrospective Single-Center Study.Endocrine · 2025Article
- Mortality factors in recurrent parathyroid cancer: a pooled analysis.Journal of bone and mineral metabolism · 2022Article
- Diagnosis and treatment of liver metastases of parathyroid carcinoma.Frontiers in endocrinology · 2022Review
- Local resection versus radical surgery for parathyroid carcinoma: A National Cancer Database analysis.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2021Article
- Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management.Frontiers in endocrinology · 2021Article
- Evaluation of malignant parathyroid tumours in two European cohorts of patients with sporadic primary hyperparathyroidism.Langenbeck's archives of surgery · 2016Article
- Parathyroid cancer.Gland surgery · 2015Review
- Diagnosis and management of parathyroid cancer.Nature reviews. Endocrinology · 2012Review
- Parathyroid carcinoma presenting as normocalcemic hyperparathyroidism.Journal of bone and mineral metabolism · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 29-year-old man presented to his primary care physician with nausea, severe weight loss and muscle weakness. He had a hard, fixed neck swelling. He was severely hypercalcaemic with 10-fold increased parathyroid hormone (PTH) concentrations. A diagnosis of primary hyperparathyroidism was established and the patient was referred for parathyroidectomy. At neck exploration, an enlarged parathyroid gland with invasive growth into the thyroid gland was found and removed, lymph nodes were cleared and hemithyroidectomy was performed. A suspected diagnosis of parathyroid carcinoma was confirmed histologically. Serum calcium and PTH levels normalised post-operatively, but hyperparathyroidism recurred within 3 years of surgery. Over the following 17 years, control of hypercalcaemia represented the most difficult challenge despite variable success achieved with repeated surgical interventions, embolisations, radiofrequency ablation of metastases and treatment with calcimimetics, bisphosphonates and haemodialysis using low-dialysate calcium. In this paper, we report the challenges and pitfalls we encountered in the management of our patient over nearly two decades of follow-up and review recent literature on the topic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.