Evidence map›Paper›PMID 21258361›Full record

ReviewCellular & molecular immunology2011

Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?

Urs Christen, Matthias G von Herrath

Open access · bronzeAbstract readReview
In one paragraph

Review in Cellular & molecular immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  12. Review
  13. Pathogen infection and autoimmune disease.Clinical and experimental immunology · 2019
    Article
  14. Pathogens and autoimmune hepatitis.Clinical and experimental immunology · 2019
    Review
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Urs ChristenPharmazentrum Frankfurt/ZAFES, Klinikum der Goethe Universität, Frankfurt am Main, Germany. christen@med.uni-frankfurt.de
Matthias G von Herrath
Goethe University Frankfurt · DELa Jolla Institute for Immunology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virus infections have been implicated in both initiation of and protection from autoimmune diseases, such as type 1 diabetes (T1D). In this review we intend to reflect on recent evidence how viruses might on the one hand be involved in the pathogenesis of T1D and on the other hand induce a state of protection from autoimmune-mediated damage. It is important to acknowledge that human individuals encounter more than just one virus infection in their lifetime. Therefore, it is important to integrate more than just one possible environmental triggering factor for autoimmune diseases to occur.

Indexed as

AnimalsDiabetes Mellitus, Type 1Disease Models, AnimalEnvironmental ExposureEpitopes, T-LymphocyteGenetic Predisposition to DiseaseHumansMolecular MimicryVirus DiseasesVirus ReplicationEpitopes, T-Lymphocyte

Identifiers

PMID21258361
PMCPMC4012874
OpenAlexW2081424082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.