ArticleNature neuroscience2011
Temporary disruption of fear-potentiated startle following PKMζ inhibition in the amygdala.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 56 citations in OpenAlex.
- Windows of change: Revisiting temporal and molecular dynamics of memory reconsolidation and persistence.Neuroscience and biobehavioral reviews · 2025Review
- PKMζ drives spatial memory reconsolidation but not maintenance.Frontiers in synaptic neuroscience · 2025Article
- Beyond reconsolidation: The need for a broad theoretical approach in clinical translations of research on retrieval-induced plasticity.Behavioral neuroscience · 2024Review
- Involvement of PKMζ in Stress Response and Depression.Frontiers in cellular neuroscience · 2022Review
- GSK-3β activation is required for ZIP-induced disruption of learned fear.Scientific reports · 2020Article
- The role of prelimbic and anterior cingulate cortices in fear memory reconsolidation and persistence depends on the memory age.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Role of prelimbic cortex PKC and PKMζ in fear memory reconsolidation and persistence following reactivation.Scientific reports · 2020Article
- Conditioned stimulus presentations alter anxiety level in fear-conditioned mice.Molecular brain · 2019Article
- Article
- Nonmuscle myosin II inhibition disrupts methamphetamine-associated memory in females and adolescents.Neurobiology of learning and memory · 2017Article
- The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain.Neural plasticity · 2017Article
- New Learning and Unlearning: Strangers or Accomplices in Threat Memory Attenuation?Trends in neurosciences · 2016Review
- Fear potentiated startle increases phospholipase D (PLD) expression/activity and PLD-linked metabotropic glutamate receptor mediated post-tetanic potentiation in rat amygdala.Neurobiology of learning and memory · 2016Article
- Article
- Intra-hippocampal administration of ZIP alleviates depressive and anxiety-like responses in an animal model of posttraumatic stress disorder.Behavioral and brain functions : BBF · 2014Article
- Early memory formation disrupted by atypical PKC inhibitor ZIP in the medial prefrontal cortex but not hippocampus.Hippocampus · 2014Article
- Does PKM(zeta) maintain memory?Brain research bulletin · 2014Review
- Protein degradation and protein synthesis in long-term memory formation.Frontiers in molecular neuroscience · 2014Review
- Inhibition of PKC disrupts addiction-related memory.Frontiers in behavioral neuroscience · 2014Article
- The ubiquitin-proteasome system as a critical regulator of synaptic plasticity and long-term memory formation.Neurobiology of learning and memory · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We examined whether protein kinase M zeta (PKMζ) inhibition in the amygdala permanently disrupts fear memory by testing retention at various intervals after PKMζ blockade. Although the expression of fear memory was disrupted when the inhibitor was applied shortly before testing, it had no effect when rats were tested with longer retention intervals. These results suggest that PKMζ inhibition does not erase memory, but temporarily disrupts expression of memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.