Evidence map›Paper›PMID 21258323›Full record

ArticleNature structural & molecular biology2011

Crystal structure of XMRV protease differs from the structures of other retropepsins.

Mi Li, Frank Dimaio, Dongwen Zhou, Alla Gustchina, Jacek Lubkowski, Zbigniew Dauter, David Baker, Alexander Wlodawer

Abstract read
In one paragraph

Article in Nature structural & molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. RNAViruses · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. AnACS catalysis · 2019
    Article
  7. Article
  8. Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.Acta crystallographica. Section D, Biological crystallography · 2015
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. High-resolution structure of a retroviral protease folded as a monomer.Acta crystallographica. Section D, Biological crystallography · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mi LiProtein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Frank Dimaio
Dongwen Zhou
Alla Gustchina
Jacek Lubkowski
Zbigniew Dauter
David Baker
Alexander Wlodawer

Funding

Protein StructureZIABC010348 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WLODAWER, ALEXANDER · 2009 to 2025
$27.5M
Macromolecular Crystallography Research with Synchrotron RadiationZIABC010378 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DAUTER, ZBIGNIEW · 2009 to 2020
$18.8M
High resolution structure modeling with RosettaR01GM092802 · NIGMS · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2010 to 2017
$2.3M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC010348NCI NIH HHS HHSN261200800001ENIGMS NIH HHS R01 GM092802
6 · The paper itself

Abstract

Using energy and density guided Rosetta refinement to improve molecular replacement, we determined the crystal structure of the protease encoded by xenotropic murine leukemia virus-related virus (XMRV). Despite overall similarity of XMRV protease to other retropepsins, the topology of its dimer interface more closely resembles those of the monomeric, pepsin-like enzymes. Thus, XMRV protease may represent a distinct branch of the aspartic protease family.

Indexed as

Amino Acid SequenceCrystallography, X-RayMolecular Sequence DataPeptide HydrolasesProtein MultimerizationViral ProteinsXenotropic murine leukemia virus-related virusPeptide HydrolasesViral Proteins

Identifiers

PMID21258323
PMCPMC3058223

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.