ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Marginal zone B cells regulate antigen capture by marginal zone macrophages.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
- Scalable, generalizable and uncertainty-aware integration of spatial multiomics across diverse modalities and platforms with SCIGMA.Nature genetics · 2026Article
- B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8Cellular & molecular immunology · 2026Article
- Defining the Role of Marginal Zone B Cells in FVIII Inhibitor Development.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Defining the Role of Marginal Zone B Cells in RBC Alloimmunization.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The STING/type I interferon axis drives the interplay between marginal zone B cells and T follicular helper cells in Sjögren's disease.Cellular & molecular immunology · 2025Article
- The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Adaptive immune cells are necessary for SARS-CoV-2-induced pathology.Science advances · 2024Article
- Bacteria-instructed B cells cross-prime naïve CD8EMBO reports · 2023Article
- Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice.Transfusion · 2022Article
- Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells.Nature communications · 2022Article
- Secondary Lymphoid Organs in Mesenchymal Stromal Cell Therapy: More Than Just a Filter.Frontiers in immunology · 2022Review
- Targeting macrophages in cancer immunotherapy.Signal transduction and targeted therapy · 2021Article
- TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases.Journal of autoimmunity · 2020Article
- Marginal zone SIGN-R1Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation.Frontiers in immunology · 2020Article
- Autoreactive B cells in SLE, villains or innocent bystanders?Immunological reviews · 2019Review
- IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8αImmunity · 2019Article
- Linking signaling and selection in the germinal center.Immunological reviews · 2019Review
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7 authors.
Funding
Abstract
The marginal zone (MZ) of the mouse spleen contains macrophages that express receptors that trap pathogens, including the scavenger receptor macrophage receptor with a collagenous structure and the C-type lectin specific intracellular adhesion molecule-grabbing nonintegrin receptor 1 (SIGN-R1). We previously reported that expression of SIGN-R1 was decreased in CD19-deficient mice. In this study, we demonstrate that SIGN-R1 is expressed on a subset of macrophage receptor with a collagenous structure (MARCO)(+) macrophages. This subset is diminished when MZ B cells are absent due to either genetic developmental defects or following transient migration of B cells out of the MZ. When B cells return to the MZ, there is a delay in recovery of SIGN-R1-expressing macrophages. During this period, capture of Ficoll, which for the macrophages requires SIGN-R1, remains defective not only by the macrophages, but also by the B cells. Thus, MZ B cells regulate expression of molecules on macrophages that are important for trapping Ag, which, in turn, is required for Ag capture by the B cells.
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