ArticleJournal of bacteriology2011
Combinatorial regulation of fmgD by MrpC2 and FruA during Myxococcus xanthus development.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Mutation of self-binding sites in the promoter of the MrpC transcriptional regulator leads to asynchronousFrontiers in microbiology · 2023Article
- Identifying the Gene Regulatory Network of the Starvation-Induced Transcriptional Activator Nla28.Journal of bacteriology · 2022Article
- Cell density, alignment, and orientation correlate with C-signal-dependent gene expression duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Article
- An ambruticin-sensing complex modulates Myxococcus xanthus development and mediates myxobacterial interspecies communication.Nature communications · 2020Article
- Ultrasensitive Response of Developing Myxococcus xanthus to the Addition of Nutrient Medium Correlates with the Level of MrpC.Journal of bacteriology · 2018Article
- TheJournal of bacteriology · 2017Article
- Highly Signal-Responsive Gene Regulatory Network Governing Myxococcus Development.Trends in genetics : TIG · 2017Review
- devI is an evolutionarily young negative regulator of Myxococcus xanthus development.Journal of bacteriology · 2015Article
- The enhancer binding protein Nla6 regulates developmental genes that are important for Myxococcus xanthus sporulation.Journal of bacteriology · 2015Article
- Combinatorial regulation of the dev operon by MrpC2 and FruA during Myxococcus xanthus development.Journal of bacteriology · 2015Article
- Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus.BMC genomics · 2014Article
- Nutrient-regulated proteolysis of MrpC halts expression of genes important for commitment to sporulation during Myxococcus xanthus development.Journal of bacteriology · 2014Article
- Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators.Nature communications · 2014Article
- The Nla28S/Nla28 two-component signal transduction system regulates sporulation in Myxococcus xanthus.Journal of bacteriology · 2012Article
- Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the role of MazF in developmental lysis.Journal of bacteriology · 2012Article
- The repertoire of DNA-binding transcription factors in prokaryotes: functional and evolutionary lessons.Science progress · 2012Review
- Combinatorial regulation by MrpC2 and FruA involves three sites in the fmgE promoter region during Myxococcus xanthus development.Journal of bacteriology · 2011Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon starvation, a dense population of rod-shaped Myxococcus xanthus bacteria coordinate their movements to construct mounds in which some of the cells differentiate to spherical spores. During this process of fruiting body formation, short-range C-signaling between cells regulates their movements and the expression of genes important for sporulation. C-signaling activates FruA, a transcription factor that binds cooperatively with another transcription factor, MrpC2, upstream of the fmgA and fmgBC promoters, activating transcription. We have found that a third C-signal-dependent gene, herein named fmgD, is subject to combinatorial control by FruA and MrpC2. The two proteins appear to bind cooperatively upstream of the fmgD promoter and activate transcription. FruA binds proximal to the fmgD promoter, as in the fmgBC promoter region, whereas MrpC2 binds proximal to the fmgA promoter. A novel feature of the fmgD promoter region is the presence of a second MrpC2 binding site partially overlapping the promoter and therefore likely to mediate repression. The downstream MrpC2 site appears to overlap the FruA site, so the two transcription factors may compete for binding, which in both cases appears to be cooperative with MrpC2 at the upstream site. We propose that binding of MrpC2 to the downstream site represses fmgD transcription until C-signaling causes the concentration of active FruA to increase sufficiently to outcompete the downstream MrpC2 for cooperative binding with the upstream MrpC2. This would explain why fmgD transcription begins later during development and is more dependent on C-signaling than transcription of fmgA and fmgBC.
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